香砂六君子汤联合奥美拉唑治疗消化性溃疡的效果分析

Analysis the effect of Xiangsha Liujunzi Decoction combined with omeprazole in the treatment of peptic ulcer

目的分析香砂六君子汤联合奥美拉唑治疗消化性溃疡的临床疗效。方法选取消化性溃疡患者60例,采用随机数字表法分为2组,各30例。对照组口服奥美拉唑,观察组在对照组的基础上予香砂六君子汤。比较2组临床治疗效果、表皮生长因子(EGF)水平、再生黏膜成熟度、Hp根除率、3个月复发率及不良反应发生情况。结果观察组治疗总有效率(93.33%,28/30)高于对照组治疗总有效率(70.00%,21/30)(P<0.05);治疗后2组EGF水平均显著升高,且观察组显著高于对照组(P<0.05),观察组再生黏膜成熟度的优良率显著高于对照组(P<0.05);观察组Hp根除率显著高于对照组(P<0.05),3个月复发率显著低于对照组(P<0.05),2组不良反应发生率比较无统计学差异(P>0.05)。结论香砂六君子汤联合奥美拉唑治疗消化性溃疡的Hp根除率高,更利于黏膜再生,复发率低,临床效果更好,且不增加不良反应发生率,具有较好的有效性和安全性。

Objective To analyze the effect of Xiangsha Liujunzi Decoction combined with omeprazole in the treatment of peptic ulcer.Methods A total of 60 cases of peptic ulcer patients were selected and divided into two groups with 30 cases in each group by random number table method.The control group received omeprazole orally,and the observation group was given Xiangsha Liujunzi Decoction on the basis of the control group.The clinical efficacy,EGF level,regenerated mucosal maturity,Hp eradication rate,3-month recurrence rate and adverse reactions were compared between the two groups.Results The total effective rate was 93.33%(28/30)in the observation group and 70.00%(21/30)in the control group,with statistical difference(P<0.05).The level of EGF was significantly increased after treatment in both groups,and the observation group was significantly higher than the control group(P<0.05),and the excellent and good rate of regeneration mucosal maturity in the observation group was significantly higher than the control group(P<0.05).The Hp eradication rate in the observation group was significantly higher than that in the control group(P<0.05),and the 3-month recurrence rate was significantly lower than that in the control group(P<0.05).There was no statistical difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Xiangsha Liujunzi Decoction combined with omeprazole in the treatment of peptic ulcer has a high Hp eradication rate,is more conducive to mucosal regeneration,low recurrence rate,better clinical effect,and does not increase the incidence of adverse reactions,with good effectiveness and safety,which is worthy of clinical reference.