加味取渊汤治疗小儿上呼吸道感染风热夹痰证的临床疗效及对血清肿瘤坏死因子-α与白细胞介素-6水平的影响

Efficacy of modified Quyuan Decoction in treating upper respiratory tract infection children with syndrome of wind-heat carrying phlegm and its effect on serum levels of TNF-αand IL-6

目的探讨加味取渊汤治疗小儿上呼吸道感染风热夹痰证的疗效以及对血清肿瘤坏死因子-α(TNF-α)与白细胞介素-6(IL-6)水平的影响。方法选取上呼吸道感染患儿88例,按随机数字表法分为对照组和观察组,各44例。对照组予头孢克洛颗粒,口服,每次20~40 mg,每日3次,最大量不超过1 g。观察组在对照组治疗基础上予加味取渊汤内服,每日1剂,每日2次。连续治疗5 d后,比较2组症状消失时间、风热夹痰证症状评分、临床疗效以及TNF-α与IL-6水平。结果观察组发热、咽痛、咳嗽消失时间明显短于对照组(P<0.01);与对照组比较,观察组治疗后风热夹痰证症状评分减少更明显(P<0.01);观察组和对照组的总有效率分别为93.18%(41/44)和75%(33/44),差异有统计学意义(P<0.05);与对照组比较,观察组治疗后血清TNF-α和IL-6水平降低更明显(P<0.01)。结论加味取渊汤治疗小儿上呼吸道感染风热夹痰证疗效明显,且可有效抑制血清TNF-α和IL-6水平。

Objective To investigate the efficacy of modified Quyuan Decoction in treating upper respiratory tract infection children with syndrome of wind-heat carrying phlegm and its effect on serum levels of tumor necrosis factor(TNF)-αand interleukin(IL)-6.Methods Eighty-eight upper respiratory tract infection children were selected and divided into control group and observation group according to random number table with 44 cases in each group.In the control group,Cefaclor granules were given orally,20-40 mg per time,3 times a day,and the maximum dose was no more than 1 g.The observation group was given modified Quyuan Decoction,one dose a day and 2 times a day on the basis of the treatment of the control group.After 5 days of continuous treatment,the disappearance time of symptom,symptom scores of syndromes of wind-heat carrying phlegm,the clinical efficacy,and serum levels of TNF-αand IL-6 were compared between the two groups.Results The disappearance time of fever,pharyngeal pain and cough in the observation group was significantly shorter than that in the control group(P<0.01).Compared with the control group,the symptoms scores of syndromes of wind-heat carrying phlegm were significantly decreased in the observation group after treatment(P<0.01).The total effective rate of observation group and control group was 93.18%(41/44)and 75%(33/44),respectively,and the difference was statistically significant(P<0.05).Compared with the control group,the serum levels of TNF-αand IL-6 in the observation group were significantly reduced after treatment(P<0.01).Conclusion Modified Quyuan Decoction has obvious therapeutic effect on upper respiratory tract infection children with syndrome of wind-heat carrying phlegm,and can effectively inhibit serum levels of TNF-αand IL-6.