雌激素作用下神经干细胞移植治疗创伤性脑损伤的研究进展

Research progress of neural stem cells with estrogen treating on traumatic brain injury

众所周知,雌激素是神经系统中一种十分重要的信号分子。近几年研究证实,雌激素对神经干细胞(NSCs)的生长发育、增殖分化具有促进作用,并且对其分化方向具有控制作用。NSCs移植治疗创伤性脑损伤(TBI)的实验研究众多,表明了NSCs的水平与TBI的恢复程度和预后密切相关。为了详细阐述最新的研究发现,本文就雌激素对NSCs的控制作用和分化方向的调控作用,以及NSCs移植治疗TBI的临床应用作一综述。

It is well known that estrogen is a very important signal molecule in the nervous system.In recent years,studies have proved that estrogen has a promoting effect on the growth and development,proliferation as well as differentiation of neural stem cells(NSCs),which having a controlling effect on the direction of their differentiation.There have also been numerous experimental studies on the treatment of traumatic brain injury(TBI)by NSCs transplantation,indicating that the level of NSCs is closely related to the recovery degree and prognosis of TBI.In order to elaborate on the latest findings,the authors will review the effects of estrogen on the control and differentiation of NSCs,as well as the clinical application of NSCs transplantation in the treatment of TBI.