短链脂肪酸与代谢性疾病相关性的研究进展

Correlation between short chain fatty acids and metabolic diseases:research progress

短链脂肪酸(SCFA)是膳食纤维经肠道菌群发酵产生的代谢产物,在维持肠道内环境与上皮细胞功能方面发挥重要作用。作为肠-脑轴交流的重要介质,SCFA与人体内多种生理功能或疾病的发生发展密切相关,其中对肠道疾病的作用已被证实。近年来的研究发现SCFA可促进机体的新陈代谢,在控制体质量、调节血糖血脂等方面具有显著效果,其与代谢性疾病的相关性已成为研究热点。虽然作用机制尚待进一步明确,但SCFA在代谢性疾病中作用与治疗潜力令人期待。

Short chain fatty acids(SCFA),metabolites produced by the fermentation of dietary fiber by intestinal flora,play important role in maintaining intestinal environment and function of epithelial cells.As an important mediator of gut-brain axis commu⁃nication,SCFA is closely related to the occurrence and development of a variety of physiological functions or diseases in human body,and its role in intestinal diseases has been confirmed.In recent years,it has been found that SCFA can promote the metabolism of the body,with a significant effect on controlling body mass and regulating blood glucose and lipid.The roles of SCFA in metabolic diseas⁃es have become a research hotspot.Although the mechanism of action remains to be clarified,the effect and therapeutic potential of SCFA for the treatment of metabolic diseases is promising.