摘要
葡萄糖转运体1(GLUT1)属于葡萄糖溶质载体2A家族,介导葡萄糖的跨膜转运。GLUT1在体内绝大多数组织中均有分布,通常以低水平表达,可维持血糖水平稳定,为各种生命活动提供能量。然而,GLUT1却异常高表达于肝癌、胰腺癌、卵巢癌等恶性肿瘤细胞,可为肿瘤的增殖、侵袭迁移提供足够的葡萄糖。通过抑制GLUT1的功能阻断肿瘤的能量来源是目前抗肿瘤药研发的热点。GLUT1还与阿尔茨海默病、糖尿病、GLUT1缺乏综合征、银屑病等疾病的发生、发展密切相关。本文主要对GLUT1的结构、组织分布、功能调节、相关疾病以及抑制剂的研发等进行综述。
Glucose transporter 1(GLUT1)belongs to glucose solute carriers 2A family and mediates the transmembrane trans⁃port of glucose.GLUT1 is widely distributed in most tissues in the body and usually expressed at low levels.It can maintain stable blood glucose levels and provide energy for various life activities.However,GLUT1 is abnormally highly expressed in malignant tumor cells such as liver cancer,pancreatic cancer,and ovarian cancer,which can provide sufficient glucose for tumor proliferation,inva⁃sion and migration.Blocking the energy source of tumors by inhibiting the function of GLUT1 is a hot spot in the development of antitu⁃mor drugs.GLUT1 is also closely related to the occurrence and development of Alzheimer′s disease,diabetes,GLUT1 deficiency syn⁃drome,and psoriasis.This article reviews the latest research progress in GLUT1 from the aspects of its structure,tissue distribution,functional regulation,related diseases and the development of inhibitors.
作者
孙燕红
扈金萍
SUN Yan-hong;HU Jin-ping(Department of Drug Metabolism,Beijing City Key Laboratory of Non-Clinical Drug Metabolism and PK/PD Study,Beijing City Key Laboratory of Active Substances Discovery and Drug Ability Evaluation,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China)
出处
《国际药学研究杂志》
CAS
北大核心
2020年第11期887-893,共7页
Journal of International Pharmaceutical Research
基金
十三五国家科技重大专项资助项目(2018ZX09711001-002)。
