影响注射用长效纳米晶混悬型注射液体内外释药因素的概述

An Overview of Factors Affecting in vivo and in vitro Release of Long-acting Injection of Nanocrystal Suspensions

近年来,长效纳米晶混悬型注射液(LAI-NS)凭借其在慢性疾病(如精神疾病、艾滋病病毒感染)治疗方面的优势而成为研究热点。本文综述了影响LAI-NS体内外释放的因素,介绍其体外释放与体内外相关性的评价方法。同时,简要介绍了局部组织炎症反应不同阶段对LAI-NS中药物颗粒吸收进入体循环的影响,以及局部组织成像技术在LAI-NS质量评价中的应用进展。期望本文能为建立LAI-NS的体内外相关性模型及质量评价体系提供参考。

In recent years,long-acting injection of nanocrystal suspensions(LAI-NS)has become a research hotspot due to its advantages in the treatment of chronic diseases[such as mental illness and human immunodeficiency virus(HIV)infection].This paper reviews the factors affecting the in vitro and in vivo release of LAI-NS,introduces the evaluation methods for in vitro release and in vivo-in vitro correlation(IVIVC).The influence factors on drug-loaded particles entering systemic circulation during local tissue inflammation process and the advances in application of local tissue imaging technology in quality evaluation of LAI-NS are briefly introduced.It is expected that this paper can provide some references for establishing IVIVC models and quality evaluation system of LAI-NS.