期刊文献+

人乳头瘤病毒抑制细胞自噬促进宫颈癌发生进展机制的研究进展 被引量:5

Research progress of mechanism of human papillomavirus inhibiting autophagy to promote the occurrence and progression of cervical cancer
下载PDF
导出
摘要 细胞自噬是在自噬相关基因的调控下利用溶酶体降解自身受损的细胞器、大分子物质和有害病原体的过程,在维持细胞存活、细胞器更新、物质循环和内环境稳定中起着重要作用。人乳头瘤病毒(human papillomavirus,HPV)感染是宫颈癌的主要病因。HPV入侵正常宿主细胞时激活细胞自噬,抑制其早期感染;同时通过其附着和内吞作用抑制细胞自噬,促进其感染。在这场博弈中,以HPV成功篡夺细胞自噬,颠覆宿主内环境,促进自身的增殖复制而胜出,最终导致宫颈癌的发生和进展。 Autophagy is a process that uses lysosomes to degrade self-damaged organelles,macromolecules,and harmful pathogens under the regulation of autophagy-related genes.It plays an important role in maintaining cell survival,organelle renewal,material circulation,and homeostasis.Human papillomavirus(HPV)infection is the main cause of cervical cancer.When HPV invades normal host cells,it activates autophagy and then inhibits its early infection.Instead,it promotes its infection by inhibiting autophagy through its attachment and endocytosis to host cells at the same time.In this game,HPV successfully usurps autophagy,overturns the host internal environment,promotes its own proliferation and replication,and eventually leads to the occurrence and progression of cervical cancer.
作者 李源源 王志莲 LI Yuanyuan;WANG Zhilian(The Second Hospital of Shanxi Medical University,Shanxi Taiyuan 030001,China)
出处 《现代肿瘤医学》 CAS 北大核心 2021年第2期352-355,共4页 Journal of Modern Oncology
关键词 细胞自噬 HPV 宫颈癌 autophagy HPV cervical cancer
  • 相关文献

参考文献1

二级参考文献6

共引文献3

同被引文献49

引证文献5

二级引证文献10

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部