乳腺癌患者血清中维生素D和淀粉样蛋白A的水平

Serum vitamin D and amyloid A levels in patients with breast cancer

目的探讨乳腺癌患者血清中维生素D和血清淀粉样蛋白A的水平。方法检测620例乳腺癌患者、250例良性乳腺纤维瘤患者及530例正常对照组血清中维生素D和血清淀粉样蛋白A的水平,收集乳腺癌患者临床病理特征资料进行统计分析。结果乳腺癌组血清25(OH)D3水平低于乳腺纤维瘤组和正常对照组(P=0.025)。乳腺癌患者血清淀粉样蛋白A水平高于乳腺纤维瘤患者组及正常对照组(P=0.005)。Spearman相关分析发现维生素D与乳腺癌分期呈负相关(r=-0.285,P=0.022),血清淀粉样蛋白A与肿瘤大小和是否有淋巴结转移呈正相关(r值分别为0.316、0.262,P<0.05)。结论乳腺癌患者血清维生素D和血清淀粉样蛋白A的浓度与乳腺癌临床分期、肿瘤大小、有无淋巴结转移相关,具有一定临床应用价值。

Objective To investigate the levels of serum vitamin D and amyloid A in patients with breast cancer. Methods A total of 620 cases with breast cancer,250 cases with benign breast cyst and 530 cases with healthy control were enrolled in this study. Serum vitamin D and amyloid A were examined and analyzed. Results Serum 25( OH)-D3 was lower in patients with breast cancer than the control group( P = 0. 025). Serum amyloid A was higher in patients with breast cancer than the control group( P = 0. 005). A negative correlation between vitamin D and breast cancer stage( r =-0. 285,P = 0. 022) was found by Spearman analysis. A positive correlation between serum amyloid A and lymph node metastasis was found( r = 0. 316,r =0. 262,P < 0. 05). Conclusion The concentration of serum vitamin D and amyloid A in breast cancer was related to clinical stage,tumor size and lymph node metastasis.