一例合并使用沙库巴曲缬沙坦和氨氯地平引起牙龈增生的因果关系判断

Judgment of cause-and-effect relationship in a case of gingival hyperplasia caused by the combination of sacubitril/valsartan and amlodipine

目的:提高临床药品不良反应(adverse drug reactions,ADRs)上报的准确性。方法:临床药师参与1例合并使用沙库巴曲缬沙坦和氨氯地平引起牙龈增生的患者的治疗过程,根据患者的病情,参考相关文献,结合药学知识、临床思维及循证医学原则,运用Naranjo’s ADRs评估量表对患者临床症状与药物是否相关作出分析,为鉴别ADRs与药物间的相关性提供依据。结果和结论:临床药师的工作避免了ADRs的误报。临床药师参与ADRs因果关系判断工作有利于准确评估用药问题,为患者提供个体化药学服务,促进临床安全、合理用药。

Objective:To improve the accuracy of clinical adverse drug reactions(ADRs)reporting.Methods:Clinical pharmacists were involved in the treatment of a case of gingival hyperplasia caused by the combination of sacubitril/valsartan and amlodipine.In accordance with the patient’s conditions,by referring to relevant literature,in combination with pharmaceutical knowledge,clinical thinking and evidence-based medical principles,Naranjo’s ADRs assessment scale was used to analyze the correlation between clinical symptoms and drugs,so that solid evidence might be available for correlation analysis between ADRs and drugs.Results and Conclusion:Clinical pharmacists’work helps to avoid false reports concerning ADRs.Clinical pharmacist involvement in the cause-and-effect judgment of ADRs is beneficial to accurate evaluation of clinical medication,helps to offer individualized pharmaceutical care for patients,and further promote clinical medication safety and rationality of drug application.