乳腺癌患者分子分型对其创伤后成长水平的影响

Effect of molecular classification of breast cancer patients on their post-traumatic growth

目的探讨乳腺癌患者分子分型对创伤后成长(PTG)水平的影响。方法本研究采用横断面调查研究,利用方便抽样法选取2019年1—12月蚌埠医学院第一附属医院收治的236例乳腺癌患者为研究对象,依据分子分型将其分为4组[Luminal A型组、Luminal B型组、人表皮生长因子受体2(HER2)阳性型组和三阴性组],采用创伤后成长量表(PTGI)分别对4组乳腺癌患者于穿刺确诊时、确诊1个月后、确诊3个月后、确诊6个月后进行问卷调查,比较各组间差异。结果乳腺癌患者PTG平均分为(51.73±9.02)分,4组乳腺癌患者穿刺确诊时PTG总分比较,差异无统计学意义(P>0.05);Luminal B型组和HER2阳性型组乳腺癌患者确诊乳腺癌6个月后的PTG总分高于确诊时的PTG总分,差异均有高度统计学意义(均P<0.01);确诊乳腺癌6月后,Luminal A型组的PTG总分比Luminal B型组低,差异有高度统计学意义(P<0.01);确诊乳腺癌6个月后,HER2阳性型组的PTG总分高于三阴性组,差异有统计学意义(P<0.05)。结论乳腺癌PTG处于中等偏下水平,Luminal B型和HER2阳性型乳腺癌患者短期内PTG变化明显,临床护理实践中要着重关注Luminal A型和三阴性型乳腺癌患者的PTG。

Objective To explore the impact of molecular classification of breast cancer patients on post-traumatic growth(PTG).Methods This study adopted a cross-sectional survey and used convenience sampling to select 236 breast cancer patients admitted to the First Affiliated Hospital of Bengbu Medical College from January to December 2019 as the research objects.According to molecular classification,they were divided into four groups(Luminal A group,Luminal B group,human epidermal growth factor receptor 2[HER2]positive group and triple negative group).The post-traumatic growth inventory(PTGI)was used to conduct questionnaire surveys on the four groups of breast cancer patients at the time of puncture diagnosis,one month after diagnosis,three months after diagnosis,and six months after diagnosis,the differences between the groups were compared.Results The average PTG score of breast cancer patients was(51.73±9.02),and there was no statistically significant difference in the total PTG score of the four groups at the time of puncture diagnosis(P>0.05).The total PTG scores of breast cancer patients in the Luminal B group and HER2 positive group at the time of six months after diagnosis were higher than the total PTG score at the time of diagnosis,and the differences were highly statistically significant(all P<0.01).At the time of six months after diagnosis,the total PTG score of the Luminal A group was lower than that of the Luminal B group,and the difference was highly statistically significant(P<0.01).At the time of six months after the diagnosis of breast cancer,the total PTG score of the HER2 positive group was higher than that of the triple negative group,and the difference was statistically significant(P<0.05).Conclusion The PTG levels of breast cancer patients are at a low-moderate level,and the PTG level of Luminal B and HER2 positive breast cancer patients have changed significantly after a short term.Clinical nursing practice should focus on the PTG of Luminal A and triple negative breast cancer patients.