中药贴敷神阙穴治疗肠梗阻效果的meta分析

Meta-analysis of traditional Chinese medicine application of shénquēpoint in the treatment of ileus

目的系统评价中药贴敷神阙穴治疗肠梗阻的临床效果。方法计算机检索万方数据库(Wanfang Data)、中国期刊全文数据库(CNKI)、中国科技期刊数据库(VIP)、美国国立医学图书馆(PubMed)、Cochrane及中国生物医学数据库等关于中药贴敷神阙穴治疗肠梗阻的随机对照试验,检索时间均为建库至2020年3月。将文献按照纳入标准与排除标准筛选,应用RevMan 5.3软件对纳入文献进行数据分析和质量评价。结果共有18个随机对照试验被纳入,共1347例肠梗阻患者。meta分析结果显示:试验组有效率高于对照组[RR=1.29,95%CI(1.22,1.37),P<0.00001],试验组的恢复自主排气时间[SMD=-1.43,95%CI(-1.91,-0.95),P<0.00001]、恢复自主排便时间[SMD=-1.30,95%CI(-1.73,-0.86),P<0.00001]、腹痛缓解时间[SMD=-1.47,95%CI(-1.83,-1.11),P<0.00001]、腹胀缓解时间[SMD=-1.51,95%CI(-2.06,-0.95),P<0.00001]、肠鸣音恢复正常时间[SMD=-1.18,95%CI(-1.60,-0.76),P<0.00001]均短于对照组。结论在常规治疗基础上予中药贴敷神阙穴治疗肠梗阻可明显提高患者治疗的有效率,改善患者临床症状及生活质量。

Objective To systematically evaluate the curative effect of traditional Chinese medicine(TCM)application of shénquēpoint on ileus.Methods The data of randomized controlled trials about TCM application of shénquēpoint treated with TCM for ileus were retrieved from Wanfang Data,CNKI,VIP,PubMed,Cochrane and CBM.The retrieval time was from the establishment time of database to March 2020.The literatures were screened according to the inclusion criteria and exclusion criteria,and the RevMan5.3 software was used to analyze the data and quality evaluation of the included literatures.Results A total of 18 randomized controlled trials were included,with 1347 patients of ileus.The meta-analysis result showed that the effective rate in the treatment group was higher than the control group(RR=1.29,95%CI[1.22,1.37],P<0.00001).The recovery time of first exhaust(SMD=-1.43,95%CI[-1.91,-0.95],P<0.00001),recovery time of first defecation(SMD=-1.30,95%CI[-1.73,-0.86],P<0.00001),time of abdominal pain release(SMD=-1.47,95%CI[-1.83,-1.11],P<0.00001),time of abdominal distension release(SMD=-1.51,95%CI[-2.06,-0.95],P<0.00001),time of borborygmus resume normal(SMD=-1.18,95%CI[-1.60,-0.76],P<0.00001)in the experimental group was shorter than those in the control group.Conclusion On the basis of conventional treatment,TCM application of shénquēpoint on ileus can obviously increase the effective rate,improve the clinical symptoms and quality of life of patients.