丙泊酚对缺血性脑损伤脑保护作用机制的研究进展

Research progress on the protective mechanism of Propofol on ischemic brain injury

缺血性脑损伤(IBI)是成人致残的主要原因之一,IBI引起神经炎症反应、氧化应激反应及细胞凋亡等使神经元受损,且IBI目前治疗手段有限。作为临床常用静脉麻醉药,丙泊酚除具有镇静催眠作用外,还具有减少脑血流、降低大脑新陈代谢的作用,其可通过磷酸肌醇3激酶(PI3K)/丝氨酸-苏氨酸蛋白激酶(Akt)通路及Toll样受体4(TLR4)/核因子(NF)-κB通路发挥抗炎作用,减少氧自由基产生以及对抗细胞凋亡等作用在缺血脑组织及神经元中发挥保护作用。丙泊酚的脑保护作用可能成为临床上治疗IBI的新靶点。

Ischemic brain injury(IBI)is one of the main causes of adult disability.IBI causes neuro-inflammation,oxidative stress and cell apoptosis to damage neurons,and current treatments for IBI are limited.As a commonly used intravenous anesthetic in clinical practice,in addition to its sedative and hypnotic effects,Propofol also has the effects of reducing cerebral blood flow and lowering brain metabolism.It can be passed through phosphoinositide 3-kinase(PI3K)/serine-threonine protein kinase(Akt)pathway and Toll-like receptor 4(TLR4)/nuclear factor(NF)-κB pathway play an anti-inflammatory effect,reduce the production of oxygen free radicals and resist cell apoptosis,and play a protective role in ischemic brain tissue and neurons.The protective effect of Propofol may become a new target for clinical treatment of IBI.