胆囊切除术后综合征中医治法及方药规律研究

Study on the traditional Chinese medicine treatment and prescription rules of postcholecystectomy syndrome

目的运用数据挖掘技术探究胆囊切除术后综合征(PCS)的中医治法及方药规律。方法检索中国知网(CNKI)、万方、维普及PubMed,以“胆囊切除术后综合征”为主题,检索时间均为建库至2019年12月31日,选择有中医药治疗的文献进行判别,建立治法方药数据库后进行频次分析、聚类分析和关联规则分析。结果中医治法主要有疏肝利胆、疏肝理气(解郁)、清热祛(除)湿等;方剂选用以柴胡疏肝散、大柴胡汤、疏肝利胆汤(自拟)等为主;前40味高频药物聚类分析可分为6个聚类方,关联规则提示支持度>40%的常用药对有6种,3药组合有3种。结论PCS可分为肝胆气郁证、肝胆湿热证、瘀血阻滞证、肝郁脾虚证、肝胃不和证和脾胃虚弱证等6个证型辨证论治,为中医临床证治提供参考。

Objective To explore traditional Chinese medicine treatment and prescription rules of postcholecystectomy syndrome(PCS)by data mining.Methods CNKI,Wanfang Data,VIP and PubMed were searched by computer,with the theme of“postcholecystectomy syndrome”,and the retrieval time was from the date of database construction to December 31,2019.The literatures with TCM treatment were selected for discrimination.After establishing the database,frequency analysis,cluster analysis and association rule analysis were carried out.Results TCM treatment included dispersing stagnated liver qi for promoting bile flow,dispersing liver and regulating qi,clearing heat and eliminating dampness,etc.The prescriptions mainly included Chaihu Shugan Powder,Da Chaihu Decoction,Shugan Lidan Decoction(self-made).Association rules suggested that there were six kinds of commonly used two-drug pairs with support>40%and three kinds of three-drug pairs.Conclusion PCS can be divided into six syndrome types:syndrome of qi stagnation of liver and gallbladder,syndrome of dampness-heat of liver and gallbladder,pattern of static blood obstruction and stagnation,syndrome of stagnation of liver qi and spleen deficiency,syndrome of incoordination between liver and stomach,and spleen-stomach weakness syndrome,which provide references for clinical treatment of TCM.