基于网络药理学挖掘治疗胃癌中药复方的研究进展

Research Progress of Compound Chinese Medicine Recipes for Treatment of Gastric Cancer Based on Network Pharmacology

胃癌是严重威胁我国居民健康的疾病,其治疗已从“手术、放疗、化疗”时代,逐步走向免疫、靶向精准医疗时代。笔者通过对比胃癌西医辨靶论治和中医辨证论治的优势与瓶颈,认为利用网络药理学方法挖掘中药复方可对中西医治疗胃癌起到促进作用。本文总结基于网络药理学挖掘中药复方治疗胃癌的研究进展,并归纳利用网络药理学挖掘中药复方治疗胃癌的模式。此方法可预测中药复方发挥作用的“多成分-多靶点-多通路-疾病”网络,探究中医辨证论治的分子作用机制。此方法可在治疗胃癌中药复方上的应用,亦可为其他治疗恶性肿瘤的药物研究提供借鉴。

Gastric cancer can cause serious threats to the health of Chinese.The treatment for gastric cancer has gradually developed from surgery,radiotherapy,chemotherapy to immune therapy and precise targeted-therapy.In this paper,we suggest that mining compound Chinese medicine recipes with network pharmacology will promote integrated Chinese and western medicine therapy for the treatment of gastric cancer by comparing the advantages and bottlenecks of western medicine target-differentiation treatment and traditional Chinese medicine(TCM)syndrome-differentiation treatment for gastric cancer.In this article,we reviewed the research progress in mining compound Chinese medicine recipes for the treatment of gastric cancer with network pharmacology,and summarized the mode of compound Chinese medicine recipes for the treatment of gastric cancer based on the mining results of network pharmacology.It is believed that the technology can predict the multi-component,multitarget,multi-pathway,disease-target regulatory network of compound Chinese medicine recipes,and can be used to explore the molecular mechanism of TCM syndrome differentiation and treatment.The application of the technology in compound Chinese medicine recipes for the treatment of gastric cancer will also provide the evidence for drug research of other malignant tumors.