摘要
目的:探讨噁拉戈利的共晶制备以及结构表征。方法:应用溶剂结晶法制备噁拉戈利-帕莫酸共晶,并采用粉末X射线衍射分析法(PXRD)、热重分析法(TG)、差示扫描量热量法(DSC)、红外光谱法(IR)等晶型结构确证方法对共晶结构进行表征,并进一步检测其稳定性。结果:筛选得到噁拉戈利-帕莫酸共晶,其供晶纯度可达99.29%。经过稳定性实验显示共晶具有良好的物理稳定性。结论:噁拉戈利-帕莫酸共晶具有良好的物理稳定性,有可能成为一个新的有效的固体药物形式。
Objective:To study the Preparation and structural characterization of co-crystal of Elagolix.Methods:The Elagolix-Pamoic acid co-crystal was successfully designed and synthesized by the solvent crystallization method,and the obtained structure was characterized by powder X-ray diffraction(PXRD),thermal Gravimetric Analysis(TG),differential scanning calorimetry(DSC),and infrared spectroscopy(IR).And the stability was tested further.Results:After co-crystal screening tests and structural characterization,it was found that the purity of Elagolix-Pamo acid co-crystal could reach 99.3%and had good stability.Conclusion:Elagolix-Pamo acid co-crystal has good physical stability,which is possible to become a new effective solid form of drug.
作者
陈晓锋
徐娟
王慧萍
李鹏
宁丽峰
CHEN Xiaofeng;XU Juan;WANG Huiping;LI Peng;NING Lifeng(National Research Institute for Family Planning, Beijing, 100081)
出处
《中国计划生育学杂志》
2020年第12期1948-1949,1954,F0002,共4页
Chinese Journal of Family Planning
基金
2016年国家重点研发计划(2016YFC1000900)
2019年中央国家机关公益性科技创新基金面上项目基金编号(KYS[2019]GJM02)。
关键词
噁拉戈利
共晶
稳定性
Elagolix co-crystalline
Co-crystal
Stability
