摘要
目的观察人参五味子汤加减联合静脉滴注阿奇霉素治疗支原体感染致大叶性肺炎(肺脾气虚证)患儿的临床疗效。方法选取2019年1月至12月芜湖市中医医院儿科病房收治的支原体感染致大叶性肺炎(肺脾气虚证)患儿90例,随机分为对照组与观察组各45例。对照组给予静脉滴注阿奇霉素抗感染及对症等综合治疗,观察组在对照组基础上给予人参五味子汤加减治疗。治疗1周后比较两组临床症状、体征及住院治疗时间;治疗前后中医肺脾气虚证评分改善;治疗前后血清炎性指标(白细胞计数、中性粒细胞、C反应蛋白)改善情况,不良反应发生情况并统计两组的临床疗效。结果两组治疗后,观察组临床症状、体征及住院时间明显低于对照组,差异有统计学意义(P<0.05);两组中医肺脾气虚证评分中主症与次症评分均低于治疗前,观察组治疗后主症与次症评分均低于对照组,差异有统计学意义(P<0.05);两组治疗后血清炎性指标(白细胞计数、中性粒细胞、C反应蛋白)水平均低于治疗前,观察组治疗后血清炎性指标(白细胞计数、中性粒细胞、C反应蛋白)水平均低于对照组,差异有统计学意义(P<0.05);两组总不良反应发生率比较无明显差异(P>0.05);观察组总有效率高于对照组,差异有统计学意义(P<0.05)。结论对于支原体感染致大叶性肺炎(肺脾气虚证)患儿,在静脉滴注阿奇霉素治疗基础上,给予人参五味子汤加减治疗,可明显改善临床症状及体征,缩短住院治疗时间,减轻炎症反应,减少抗菌药物的使用,安全性较好。
Objective To observe the clinical efficacy of Ginseng-Schisandrae decoction combined with intravenous azithromycin in the treatment of children with lobar pneumonia caused by mycoplasma infection(syndrome of qi deficiency of lung and spleen).Methods From January to December 2019,90 cases of lobar pneumonia(syndrome of qi deficiency of lung and spleen)caused by mycoplasma infection admitted to Pediatric Department in Wuhu Traditional Chinese Medicine Hospital were divided into treatment group and control group according to random number table method,with 45 cases in each group.Both groups were treated with azithromycin for anti-infection and symptomatic treatment,and the observation group was also treated with Ginseng-Schisandrae decoction.After 1 week of treatment,the clinical symptoms,signs and hospitalization time of the two groups were compared.The improvement in the scores of TCM syndrome of qi deficiency of lung and spleen before and after treatment,the improvement in serum inflammatory indicators(white blood cell count,neutrophils,C-reactive protein)before and after treatment,and the occurrence of adverse reactions were compared,and the clinical efficacy of the two groups were counted.Results After treatment,the clinical symptoms,signs and hospitalization time in the observation group were significantly lower than those in the control group,with statistically significant differences(P<0.05).The scores of primary and secondary symptoms of syndrome of qi deficiency of lung and spleen in the two groups were lower after treatment than before treatment,and those in the observation group were lower than those in the control group,with statistically significant differences(P<0.05).The serum inflammatory indicators(white blood cell count,neutrophils,C-reactive protein)of the two groups after treatment were all lower than those before treatment,and the serum inflammatory indicators of the observation group were all lower than those of the control group,with statistically significant differences(P<0.05).There was no significant difference in the incidence of total adverse reactions between the two groups(P>0.05).The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion For the children with lobar pneumonia caused by mycoplasma infection(syndrome of qi deficiency of lung and spleen),giving Ginseng-Schisandrae decoction on the basis of intravenous azithromycin treatment can significantly improve clinical symptoms and signs,shorten the length of hospital stay,reduce inflammatory reactions and reduce the use of antibiotics,and It is safer.
作者
毛庆东
MAO Qingdong(Department of Pediatrics,Wuhu Traditional Chinese Medicine Hospital,Wuhu 241002,China)
出处
《中国中西医结合儿科学》
2020年第6期530-533,共4页
Chinese Pediatrics of Integrated Traditional and Western Medicine
关键词
大叶性肺炎
支原体感染
人参五味子汤
阿奇霉素
临床疗效
儿童
Lobar pneumonia
Mycoplasma infection
Ginseng-Schisandrae decoction
Azithromycin
Clinical efficacy
Children