TNF-α、IL-10在咳嗽变异性哮喘患儿诊断中的价值分析

Analysis of the diagnostic value of TNF-αand IL-10 in children with cough variant asthma

目的探讨肿瘤坏死因子-α(TNF-α)、白介素-10(IL-10)在咳嗽变异性哮喘患儿诊断中的价值。方法选取2018年3月至2019年5月某院收治的咳嗽变异性哮喘患儿62例,感染性咳嗽患儿80例,并选取同期接受体检的健康儿童80例,三组均接受TNF-α、IL-10水平检测。结果相较于对照组与感染性咳嗽组,咳嗽变异性哮喘组的TNF-α水平更高,IL-10水平更低,差异具有高度统计学意义(P<0.001);相较于对照组,感染性咳嗽组的TNF-α水平更高,IL-10水平更低,差异具有高度统计学意义(P<0.001);相较于咳嗽变异性哮喘发作时间<15 d的患儿,咳嗽变异性哮喘发作时间≥15 d的患儿TNF-α水平更高,IL-10水平更低,差异具有统计学意义(P<0.05);咳嗽变异性哮喘组与感染性咳嗽组患儿治疗后TNF-α低于治疗前,IL-10水平高于治疗前,差异具有统计学意义(P<0.05);开展直线相关性分析可知,TNF-α水平与咳嗽持续时间表现为正相关(r=0.58,P<0.05),IL-10与咳嗽持续时间表现为负相关(r=-0.65,P<0.05)。结论TNF-α、IL-10检测可为咳嗽变异性哮喘患儿诊断提供参考,同时可在咳嗽变异性哮喘与感染性咳嗽鉴别中发挥价值。

Objective To investigate the value of tumor necrosis factor-α(TNF-α)and interleukin-10(IL-10)in the diagnosis of cough variant asthma among children.Methods Sixty-two children with cough variant asthma and 80 children with infectious cough admitted to a hospital from March 2018 to May 2019 were selected,and 80 healthy children who underwent physical examination during the same period were selected.TNF-and IL-10 levels were detected in all three groups.Results Compared with the control group and the infectious cough group,the levels of TNF-αand IL-10 in the cough variant asthma group were higher,and the differences were statistically significant(P<0.05).Compared with the control group,the levels of TNF-αand IL-10 in the infectious cough group were higher,and the differences were statistically significant(P<0.05).The levels of TNF-αwere higher and IL-10 lower in children with cough variant asthma for more than and equal to 15 days than those with cough variant asthma for less than 15 days,with statistically significant differences(P<0.05).After treatment,TNF-αlevels in the cough variant asthma group and the infectious cough group were lower than those before treatment,and IL-10 levels higher than those before treatment,and the differences were statistically significant(P<0.05).The straight-line correlation analysis showed that TNF-αlevel was positively correlated with cough duration(r=0.58,P<0.05),while IL-10 was negatively correlated with cough duration(r=-0.65,P<0.05).Conclusion The detection of TNF-αand IL-10 can provide reference for the diagnosis of children with cough variant asthma,which plays a valuable role in the differentiation of cough variant asthma and infectious cough.