姜黄素及其类似物辅助奥沙利铂治疗的研究进展

Study progress of curcumin and its analogues in oxaliplatin therapy

奥沙利铂(oxaliplatin,OXA)为第三代铂类抗肿瘤药物,因其高效的抗肿瘤特性,目前已被广泛用于治疗以结直肠癌为主的各种人类恶性肿瘤。但OXA的应用仍存在一定的不良反应:如神经毒性、骨髓抑制、胃肠道反应、肝损伤等,同时由于部分肿瘤会产生对OXA的耐药性,使其治疗效果受到影响。姜黄素是一种来源于植物姜黄并具有抗肿瘤、抗氧化等多种药理活性的单体物质。近年来的系列研究表明,姜黄素及其合成类似物与奥沙利铂联用,可增强OXA细胞毒性并提升抗肿瘤效果,同时姜黄素还可发挥抑制血管生成和侵袭转移、减弱肿瘤细胞耐药性和减轻OXA氧化损伤等作用。本文综述了姜黄素和OXA联合使用的体内外抗肿瘤研究结果,并阐明可能的相关机制,为姜黄素类物质增益OXA治疗提供了有效证据。

Oxaliplatin(OXA) is a third-generation platinum anti-tumor drug. Due to its highly effective anti-tumor properties, OXA has been widely used in the treatment of various human malignant tumors, mainly colorectal cancer. However, the application of OXA still has some side effects, such as neurotoxicity, bone marrow suppression, gastrointestinal reactions, liver injury, and so on. At the same time, some tumors may develop resistance to OXA, which affects its therapeutic effect. Curcumin is a monomer substance derived from turmeric, which has multiple types of pharmacological activities such as anti-tumor and anti-oxidation. In recent years, a series of studies have shown that curcumin and its synthetic analogues combined with oxaliplatin can enhance the cytotoxicity of OXA and strengthen the anti-tumor effect, while curcumin can also play a role in inhibiting angiogenesis, invasion and metastasis, reducing drug resistance of tumor cells and lowering oxidative damage of OXA. In this paper, we reviewed the anti-tumor research results of curcumin combined with OXA in vivo and in vitro, and elucidated the possible mechanisms, which could provide effective evidence for curcumin compounds to enhance OXA therapy.