钠通道NaV1.9与疼痛的研究进展

Research Progress of Sodium Channel NaV1.9 and Pain

电压门控钠通道NaV1.9特异性表达于外周伤害感受器,在神经电信号产生和传导的过程中扮演着重要角色。动物模型和临床遗传学研究表明,其在炎性疼痛、神经性疼痛和冷痛中具有重要作用,是一个潜在的镇痛药物研发靶点。本文从NaV1.9的表达定位、生理学特性、疼痛动物模型研究、临床相关疼痛疾病研究和药理学研究这几个方面对NaV1.9与疼痛关系进行综述,探讨靶向镇痛药物开发,为深入研究Nav1.9在疼痛中的重要角色提供参考。

Voltage-gated sodium channel NaV1.9 is preferentially expressed in peripheral nociceptors and plays an important role in the generation and propagation of electrical signals in nerves.Animal models and genetic studies have shown that it plays a major role in inflammatory pain,neuropathic pain and cold allodynia.Therefore,NaV1.9 is a potential target for analgesics.Here,we review recent studies that reveal the relationship between NaV1.9 and pain.NaV1.9’s expression location,physiological characteristics,animal models,genetic validation in humans and pharmacological study,and the development of targeted analgesics were discussed,to provide reference for the further research of the role of NaV1.9 in pain.