非酒精性脂肪性肝病与消化道肿瘤的相关研究进展

Research progress of non-alcoholic fatty liver disease and gastrointestinal tumors

非酒精性脂肪性肝病(NAFLD)是代谢综合征的肝脏表现,易合并心脑血管疾病、内分泌疾病、慢性肾脏病、阻塞性睡眠呼吸暂停综合征、骨质疏松症等肝外疾病,近年来众多研究发现NAFLD患者多种肝外恶性肿瘤患病率增高,并以消化道肿瘤患病率最高,本文就NAFLD与消化道肿瘤的相关研究进展及其可能的分子机制进行综述。

Non-alcoholic fatty liver disease(NAFLD)is the liver manifestation of metabolic syndrome,which is easy to be combined with cardio-cerebrovascular disease,endocrine disease,chronic kidney disease,obstructive sleep apnea syndrome,osteoporosis and other extrahepatic diseases.In recent years,many studies have found that the prevalence of multiple extrahepatic malignant tumors in NAFLD patients increased,with the highest incidence of gastrointestinal tumors.This article reviews the progress of the studies on the correlation between NAFLD and gastrointestinal tumors and the underlying molecular mechanisms of tumorigenesis.