构建中医个体化长时程疗效评价方法

Construction of the evaluation method of personalized dynamic efficacy for traditional Chinese medicine from the perspective of the long time course

个体化是中医临床诊疗的突出特点和表现形式,由此带来的疗效评价难题长期限制中医优质证据的产生。立足于时空特征下个体诊疗信息的复杂性和动态性,借鉴系统科学时空观的理论思想,分析中医个体诊疗数据特征,本文总结概括出长时程疗效评价理念,进而从临床评价的起始源头-临床问题要素(PICO)的构建入手,在长时程视角下引入动态评价要素,探索构建中医个体化疗效评价方法,为后续中医个体化临床研究的设计和实施提供示范和参考。

The prominent feature and form of clinical diagnosis and treatment of traditional Chinese medicine is individualization,which has generated difficulty for clinical evaluation and has restricted the production of high-level evidence for traditional Chinese medicine for a long time.Based on the complexity and dynamics of individualized information under the characteristics of time and space,this paper references the theory of space-time of system science to analyze the individualized data of diagnosis and treatment of traditional Chinese medicine and summarizes the concept of the long time course for clinical evaluation.Based on the concept of the long time course,this paper starts with the origin of clinical evaluation,which is the construction of clinical problem elements named PICO,introduces dynamic evaluation factors,explores the construction of individualized dynamic evaluation method of traditional Chinese medicine,and provides demonstration and examples for the design and implementation of individualized clinical research in future.