利福平胶囊(Ⅱ)治疗肺结核的临床效果及对患者肝功能的影响

Clinical effect of rifampicin capsule(Ⅱ)in the treatment of pulmonary tuberculosis and its effect on liver function

目的:探析利福平胶囊(Ⅱ)治疗肺结核的临床效果及对患者肝功能的影响。方法:2016年5月-2020年5月收治肺结核初诊治患者108例,随机分为两组,各54例。对照采用利福平胶囊治疗,观察组选择利福平胶囊(Ⅱ)治疗,比较两组临床疗效、肝功能指标水平、痰菌转阴情况及不良反应发生率。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05);观察组血清丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、直接胆红素(DBIL)水平优于对照组,差异有统计学意义(P<0.05);观察组治疗1个月、2个月后痰菌转阴率高于对照组,观察组发生不良反发生率低于对照组,差异均有统计学意义(P<0.05)。结论:初诊治疗肺结核时选择利福平胶囊(Ⅱ)疗效显著。

Objective:To explore the clinical effect of rifampicin capsule(Ⅱ)in the treatment of pulmonary tuberculosis and its effect on liver function.Methods:From May 2016 to May 2020,108 patients with pulmonary tuberculosis were selected,they were randomly divided into the two groups with 54 cases in each group.The control group was treated with rifampicin capsule.The observation group was treated with rifampicin capsule(Ⅱ).The clinical efficacy,the level of liver function index,the negative conversion of sputum bacteria and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was significantly higher than that of the control group,the difference was statistically significant(P<0.05).The levels of serum alanine aminotransferase(ALT),aspartate aminotransferase(AST)and direct bilirubin(DBIL)in the observation group were better than those in the control group,the difference was statistically significant(P<0.05).After 1 and 2 months of treatment,the sputum negative conversion rate of the observation group was higher than that of the control group,and the incidence of adverse reaction in the observation group was lower than that of the control group,the differences were statistically significant(P<0.05).Conclusion:Rifampicin capsule(Ⅱ)is selected for the first diagnosis and treatment of tuberculosis,and the effect is significant.