预防性应用抗生素对肝硬化上消化道出血患者感染的效果分析

Analysis of the effect of prophylactic application of antibiotics on infection in cirrhotic patients with upper gastrointestinal bleeding

目的:探讨预防性应用抗生素对肝硬化上消化道出血患者感染的效果分析。方法:2016年1月-2019年9月收治肝硬化上消化道出血患者90例,随机分为两组,各45例。对照组采用常规治疗,观察组采用预防性应用抗生素治疗,比较两组患者临床疗效、预后效果及感染情况。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05);观察组治疗后再出血、感染、不良反应发生率均低于对照组,差异有统计学意义(P<0.05);观察组治疗后感染发生率低于对照组,差异有统计学意义(P<0.05)。结论:预防性应用抗生素对肝硬化上消化道出血患者预防感染效果良好,能显著降低患者感染情况发生。

Objective:To explore the effect of prophylactic application of antibiotics on infection in cirrhotic patients with upper gastrointestinal bleeding.Methods:From January 2016 to September 2019,90 patients with liver cirrhosis and upper gastrointestinal bleeding were selected,they were randomly divided into the two groups with 45 patients in each group.The control group was treated with routine treatment.The observation group was treated with prophylactic antibiotics.The clinical efficacy,prognosis and infection were compared between the two groups.Results:The total effective rate of the observation group was significantly higher than that of the control group,the difference was statistically significant(P<0.05).The incidences of rebleeding,infection and adverse reactions in the observation group were significantly lower than those in the control group,the difference was statistically significant(P<0.05).The incidence of infection in the observation group was significantly lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion:Prophylactic application of antibiotics is effective in preventing infection in cirrhosis patients with upper gastrointestinal bleeding,and can significantly reduce the incidence of infection.