原发性肾小球疾病10年病理特征对比研究

Comparative study on pathological characteristics of primary glomerular disease in 10 years

目的:总结梳理原发性肾小球疾病(PGD)10年内病理特征变化,为今后PGD的临床防治工作提供参考。方法:选取2010年2月-2020年3月接受肾活检后确诊为PGD的患者305例,将2010年2月-2015年2月的124例作为早期组,将2015年3月-2020年3月的181例作为当前组,对比两组患者流行病学特征与病理类型分布特征。结果:两组性别构成及文化程度比较,差异无统计学意义(P>0.05);当前组患者平均年龄低于早期组,差异有统计学意义(P<0.05)。当前组膜性肾病(MN)占比高于早期组,IgA肾病占比低于早期组,差异有统计学意义(P<0.05)。结论:近5年来原发性肾小球疾病的发病年龄呈现年轻化趋势,原发性小球疾病中膜性肾病的发病率升高,位居原发性肾小球疾病各病理类型首位。

Objective:To compare the pathological changes of primary glomerular disease(PGD)in 10 years,and to provide reference for clinical prevention and treatment of PGD in the future.Methods:From February 2010 to March 2020,305 patients with PGD confirmed by renal biopsy were selected,124 cases from February 2010 to February 2015 were selected as the early group,and 181 cases from March 2015 to March 2020 were selected as the current group.We compared the epidemiological and pathological characteristics of the two groups.Results:There was no significant difference in gender composition and educational level between the two groups(P>0.05).The average age of the current group was lower than that of the early group,the difference was statistically significant(P<0.05).In the current group,the proportion of membranous nephropathy(MN)was higher than that of early group,and the proportion of IgA nephropathy was lower than that of early group,the difference was statistically significant(P<0.05).Conclusion:In the past five years,the onset age of primary glomerular disease has turned younger,in primary glomerulopathy,the incidence rate of membranous nephropathy has increased,ranking the first place in all pathological types of primary glomerular diseases.