细胞自噬与肝功能衰竭

Autophagy in the liver failure

肝功能衰竭是肝脏组织发生大块或亚大块坏死的严重肝病症候群,其病情发展迅速,临床预后差,病死率极高。近年来,细胞自噬在肝功能衰竭中所起的作用越来越受到关注。深入研究细胞自噬的调控机制对肝功能衰竭的预防和治疗具有重要意义。现根据国内外研究进展,探索肝功能衰竭中细胞自噬与坏死、凋亡的关系,并就自噬在肝功能衰竭各阶段的作用机制及表达水平进行总结,希望能够为肝功能衰竭的深入研究及临床治疗提供参考。

Liver failure is a severe liver disease syndrome,with massive or sub-massive liver tissues necrosis,and it develops rapidly,with poor clinical prognosis and high mortality.In recent years,autophagy role in the liver failure has received increasing attention.The study of the role of regulatory mechanism of autophagy is of great significance for the in-depth study of the prevention and treatment of liver failure.Based on the research progress of liver failure at home and abroad,this paper explores and summarizes the relationship between autophagy with necrosis and apoptosis,as well as the mechanism and expression level of autophagy in each stage of liver failure,with hope to provide reference for the in-depth research and clinical treatment of liver failure.