舟山群岛居民高尿酸血症及痛风的影响因素分析

Influencing factors of hyperuricemia and gout among residents in the Zhoushan Archipelago

目的调查舟山群岛地区居民高尿酸血症(hyperuricemia,HUA)和痛风的患病率,探讨高尿酸血症的患病危险因素。方法对2016年7月-2017年6月于舟山医院体检中心进行体检的人群进行调查研究。调查了5 745名成年人高尿酸血症和痛风的患病情况。结果 HUA患病率23.2%,标化率为20.4%;其中男性为13.0%,女性为38.8%。痛风患病率为1.9%,标化率为2.0%;其中男性为2.7%,女性为0.8%。HUA患者痛风的患病率为1.7%。整体人群血尿酸水平为(341.1±71.4)μmol/L,男性血尿酸水平为(350.0±78.3)μmol/L,女性(327.4±56.5)μmol/L。痛风组患病年龄、血压、血糖、血尿酸、甘油三酯水平均高于正常组(P<0.05),HUA组血糖、血压、血尿酸和胆固醇水平均高于正常组(P<0.05),痛风组和HUA组肌酐清除率均小于正常组(P<0.05)。Logistic多因素回归分析显示,血压、高胆固醇和肾功能异常是HUA的危险因素。结论舟山群岛居民HUA和痛风患病率较高,尤其女性HUA患病率明显高于国内其他地区的调查结果需采取相应措施降低居民HUA和痛风的患病率。

Objective To investigate the prevalence rates of hyperuricemia(HUA) and gout in residents in the Zhoushan Archipelago, and to explore the risk factors of HUA. Methods A study was carried out in population who had physical examination in the Health Guidance Center of Zhoushan Hospital from July 2016 to June 2017. The prevalence rates of HUA and gout in 5,745 adults were investigated. Results The prevalence rate of HUA was 23.2%, and the standardized rate was 20.4%, of which the prevalence rates in males and females were 13.0% and 38.8%, respectively. The prevalence rate of gout was 1.9%, and the standardized rate was 2.0%, of which the prevalence rates in males and females were 2.7% and 0.8%, respectively. The prevalence rate of gout in patients with HUA was 1.7%. The average level of serum uric acid was(341.1±71.4) umol/L, with(350.0±78.3) umol/L in males and(327.4±56.5) umol/L in females. Age and levels of blood pressure, blood sugar, serum uric acid and triglyceride were significantly higher in the gout group than in the normal group(all P<0.05). Levels of blood pressure, blood sugar, serum uric acid and total cholesterol were significantly higher in the HUA group than in the normal group(all P<0.05). Creatinine clearance rate was lower in the gout group and the HUA group than in the normal group(both P<0.05). Logistic multivariate regression analysis showed that blood pressure, hyperlipidemia and abnormal renal function were risk factors for HUA. Conclusions The prevalence rates of HUA and gout in residents in the Zhoushan Archipelago are high, especially in women, which is significantly higher than those in other parts of China. Corresponding countermeasures should be taken to reduce the prevalence rates of HUA and gout in the residents.