药物联合正念认知疗法对抑郁症患者康复获益的影响

The effects of drug combined with mindfulness-based cognitive therapy on rehabilitation benefits of depressive patients

目的分析药物联合正念认知疗法对抑郁症患者康复获益的影响。方法将2019年7月-2020年7月在本院心身医学科接受治疗的抑郁症70例患者随机分为干预组(36例)和对照组(34例),干预组给予盐酸文拉法辛联合正念认知疗法,对照组仅予盐酸文拉法辛治疗,于住院前和出院时用汉密尔顿抑郁量表(HAMD--24)、症状自评量表(SCL-90)和社会功能缺陷量表(SDSS)进行评定,比较两组患者抑郁症状及社会功能改善情况,并对两组患者治愈率及平均住院时间做对照分析。结果①平均住院时间干预组为24.78±2.45天,对照组为29.02±2.24天,干预组明显少于对照组,差异具有统计学意义(P<0.01)。②出院时治愈率干预组为75.0%,对照组为55.%,干预组高于对照组,但差异无统计学意义(P>0.05)。③HAMD-24、SDSS、SCL-90评分干预前干预组和对照组差异无统计学意义(P>0.05);干预后HAMD-24评分、SDSS评分,SCL-90评分中躯体化、人际关系敏感、抑郁、焦虑评分差值干预组均大于对照组,差异具有统计学意义(P<0.01);SCL-90评分中强迫、敌对、恐怖、偏执及精神病性因子分差值干预组和对照组差异无统计学意义(P>0.05)。结论药物联合正念认知疗法能够缩短患者平均住院时间,在促进患者抑郁症状恢复、改善社会功能和提高生活质量的康复获益影响上更具优势。

Objective To analyze the effects of drug combined with mindfulness-based cogni­tive therapy(MBCT)on rehabilitation benefits of depressive patients.Methods Depressed pa­tients who were treated in the Psychosomatic Medicine department in the hospital from July 2019 to July 2020 were randomly assigned into intervention group(36 cases)and control group(34 cas­es),patients in intervention group received venlafaxine hydrochloride teatment and MBCT,patients in control-group received venlafaxine hydrochloride treatment.The Hamilton Depression Scale(HAMD-24),Self-rating Symptom Scale(SCL-90)and Social Disability Screening Scale(SDSS)were used to evaluate the depressive symptoms and the improvement of social function of pa­tients in the two groups before and after hospitalization,and the cure rate and average length of hospital stay were compared between the two groups.Results①The average length of hospital stay in the intervention group(24.78±2.45 ds)and control group(29.02±2.24 ds),the difference was statistically significant(P<0.01).②The cure rate at discharge was 75.0%in the intervention group and 55.9%in the control group,which was higher than the control group,but the difference was not statistically significant(P>0.05).③HAMD-24,SDSS,and factors of SCL-90 scores showed no statistically significant difference between the two groups before intervention(P>0.05);After intervention,HAMD-24,SDSS and factors of SCL-90(Somatization,interpersonal sensitivity,depression,anxiety)score differences before and after the treatment in intervention group were higher than those in control group,difference was statistically significant(P<0.01);Factors of SCL-90(Coercion,hostility,terror,paranoia,and psychosis)score differences before and after the treat­ment between the two group was not statistically significant(P>0.05).Conclusion Drug combined with MBCT can shorten the average length of hospital stay,and has more advantages in promot­ing the recovery of depressive symptoms,improving social function and quality of life of depres­sive patients.