干扰素抗诺如病毒感染的研究进展

Research Progress in Use of Interferon Against Norovirus Infection

人诺如病毒(Human norovirus,HuNV)是导致全世界急性胃肠炎散发病例和暴发疫情的主要病原体,疾病负担严重,目前没有有效针对HuNV的抗病毒药物或疫苗。HuNV引起的胃肠炎的病程通常只持续1~3 d,因此先天免疫应答在控制HuNV感染中起重要作用。干扰素(Interferon,IFN)是一类具有抗病毒、调节免疫等作用的糖蛋白。IFN对控制诺如病毒(Norovirus,NV)的复制非常关键,本文主要对Ⅰ型IFNs和Ⅲ型IFNs的抗NV感染的免疫作用进行综述,希望为HuNV与IFN之间的相互作用关系与机制及抗HuNV治疗提供有效信息。

Human noroviruses(HuNVs)are the main pathogens causing sporadic outbreaks of acute gastroenteritis worldwide.The disease burden is heavy,and an efficacious antiviral drug/vaccine against NVs is lacking.The course of HuNV-induced gastroenteritis usually lasts only 1 to 3 days,so the innate immune response plays an important part in controlling HuNV infection.Interferon is a type of glycoprotein with antiviral and immunomodulatory effects.Interferon is very important for control of NV replication.In recent years,several studies have focused on the effect of interferon against NV infection.We reviewed the immune effects of type-Ⅰand type-Ⅲinterferons against NV infection.We hope that this review can provide important information on the interaction and mechanism between NVs and interferon,and anti-HuNV therapy.