基于生殖内分泌调控胃动素相关肽研究进展

Research Advances of Motilin-Related Peptides Based on Reproductive Endocrine Regulation

生长激素释放肽(Ghrelin)又名"胃饥饿素""胃动素相关肽",是目前研究最多的脑-肠肽。Ghrelin不仅可以在中枢神经系统层面调节机体内分泌,还可以直接作用于卵巢、卵泡而发挥多种调控作用,与女性生殖内分泌疾病密切相关,尤其是与多囊卵巢综合征及多囊卵巢综合征合并胰岛素抵抗的发病相关。近年来,中医学者开始关注胃肠功能紊乱(Ghrelin分泌异常)与女性生殖内分泌的关系,治疗上以Ghrelin为靶点取得了较好的疗效。该文就最近10年Ghrelin对女性生殖内分泌调控作用及中医药对Ghrelin的研究综述如下。

Growth hormone releasing peptide,also known as"motilin-related peptide",is the most studied brain-gut peptide.Ghrelin can regulate the secretion of the body at the central nervous system level,and can directly exert effects on the ovary and follicles.Therefore,Ghrelin is closely related to female reproductive endocrine diseases,especially in the pathogenesis of polycystic ovary syndrome(PCOS)and polycystic ovary syndrome with insulin resistance(PCOS-IR).In recent years,Chinese medicine practitioners have begun to pay attention to the relationship between gastrointestinal dysfunction(abnormal Ghrelin secretion)and female reproductive endocrine.Ghrelin has been used as a target for treatment.This article summarizes the research of Ghrelin on female reproductive endocrine regulation and traditional medicine on Ghrelin in the last 10 years.