Binder综合征的超声表现及预后分析

Ultrasonographic manifestations and prognosis of Binder’s syndrome

目的:探讨胎儿期Binder综合征的超声表现及其预后.方法:回顾性分析我院产前超声检查发现的23例Binder综合征胎儿的资料,进行出生后发育随访,分析所有胎儿超声声像图表现及临床结局.结果:23例Binder综合征典型面部表现胎儿中,单纯性典型面部表现者6例,合并其他异常者17例,1例基因检测证实为骨发育不良引产,5例终止妊娠,2例失访,余15例胎儿随访至2月~3岁.2例患儿身姿轻度异常,1例胎儿身高、智力稍落后于同龄儿,余身高及智力暂未发现明显异常.结论:超声检查通过胎儿典型颜面部表现对诊断Binder综合征有重要意义.了解Binder综合征的预后对产前咨询具有重要价值.

Objective:To investigate the ultrasonographic manifestations and prognosis of Binder’s syndrome in fetuses.Methods:Retrospective analysis of 23 cases of fetuses with Binder’s syndrome detected by prenatal ultrasound in our hospital.The development of all the fetuses were followed up after birth,the ultrasonographic features and clinical outcomes of all the fetuses were analyzed.Results:Among the 23 fetuses with Binder’s syndrome,six fetuses with typical facial manifestations,and 17 fetuses with typical facial manifestations combined with other abnormal manifestations.One fetus was induced labor due to fatal osteodysplasia by genetic test,five cases were terminated of pregnancy,two cases were lost follow-up,and the remaining 15 cases were followed up from 2 months to 3 years.Two cases were slightly abnormal in posture,one was slightly behind the same age in height and intelligence,and the rest were no significant abnormality in height and intelligence.Conclusions:The typical facial expression by ultrasonography is important for the diagnosis of Binder’s syndrome in fetus.It is of great value to understand the prognosis of Binder’s syndrome in clinical prenatal consultation.