肠道菌群与围手术期神经认知功能障碍

Gut microbiota and perioperative neurocognitive disorder

围手术期神经认知功能障碍(perioperative neurocognitive disorder,PND)是手术患者围手术期常见并发症之一,在临床上受到广泛关注。随着老年人口的逐渐增多,个体疾病复杂性随之增加,PND发生风险越来越高,成为研究者们最为关注的并发症之一。近年来大量研究证实肠道菌群与神经系统疾病存在密切关系,亦有种种研究证明肠道菌群可能参与了PND的发生发展。该文就目前研究成果,从肠道菌群对PND的影响、可能机制和干预措施方面进行一个总结论述,为PND的研究和治疗提供新思路。

Perioperative neurocognitive disorder(PND)is one of the common perioperative complications in surgical patients,which has been concerned by most researchers.With the gradual increase of the elderly population in China,the complexity of individual diseases and the risk of PND is more and more severe.In recent years,a large number of studies have confirmed the close relationship between intestinal flora and neurological diseases and various studies have also proved that gut microbiota may contribute to the occurrence and development of PND.Based on the current studies,this article summarizes the effects of gut microbiota on PND,including possible mechanisms and intervention measures,providing some ideas for researchers and treatment of PND.