基于“虚、毒”病机理论的体舒颗粒对改善围手术期脾虚型大肠癌患者营养不良状态的临床研究

Clinical Study on Tishu Granule in Theory of“Virtual and Toxicity”to Improve Malnutrition Status in Patients with Colorectal Cancer of Perioperative Spleen Deficiency Type

目的基于"虚、毒"病机理论,观察体舒颗粒对改善围手术期脾虚型大肠癌患者营养不良状态的临床疗效。方法将2017年5月-2019年5月于辽宁中医药大学附属第三医院住院手术且符合实验要求的120例大肠癌患者,随机分成观察组和对照组,各60例。对照组术前、术后予以肠内营养混悬液(能全力)治疗,观察组术前、术后予以肠内营养混悬液(能全力)和体舒颗粒同时治疗。比较两组术后8 d、术后15 d白蛋白、前白蛋白、转铁蛋白含量,血红蛋白、总胆固醇、甘油三酯、低密度脂蛋白含量和血T细胞亚群。结果术后8 d两组白蛋白、前白蛋白、转铁蛋白含量,血红蛋白、总胆固醇、甘油三酯、低密度脂蛋白含量和血T细胞亚群CD4+/CD8+比值均无明显差异(P>0.05);术后15 d两组白蛋白、前白蛋白、转铁蛋白含量均存在差异(P<0.05);术后15 d两组血红蛋白、总胆固醇、甘油三酯、低密度脂蛋白含量均存在差异(P<0.05);术后15天观察组CD4+/CD8+比值,与对照组比较存在统计学意义(P<0.05)。结论体舒颗粒改善围手术期脾虚型大肠癌患者营养不良状态有效。

Objective To observe the clinical effect of Tishu Granule on improving the malnutrition status of patients with spleen-deficiency colorectal cancer in perioperative period based on the pathogenesis of"virulent toxicity".Methods Totally 120 patients with colorectal cancer admitted to the Third Affiliated Hospital of Liaoning University of Traditional Chinese Medicine from May 2017 to May 2019 were randomly divided into observation group and control group,with 60 cases in each group.The control group was treated with Enteral Nutrition Suspension(Pepti Son)before and after surgery.The observation group was treated with Enteral Nutrition Suspension(Pepti Son)and Tishu Granule before and after surgery.Albumin,albumin,transferrin content,hemoglobin,total cholesterol,triglyceride,low density lipoprotein content and blood T cell subsets were compared between the two groups at 8 and 15 days postoperatively.Results There was no significant difference in the ratio of albumin,prealbumin,transferrin,hemoglobin,total cholesterol,triglyceride,low density lipoprotein and blood T cell CD4+/CD8+subsets on day 8 after surgery(P>0.05).Albumin,prealbumin and transferrin levels were different between the two groups on the 15 th day after surgery(P<0.05).Hemoglobin,total cholesterol,triglycerides and low density lipoprotein were measured 15 days after surgery.The difference was statistically significant(P<0.05).The proportion of CD4+/CD8+in the observation group 15 days after operation was statistically significant compared with that of the control group(P<0.05).Conclusion Tishu Granule can effectively improve the perioperative malnutrition status of patients with colorectal cancer and spleen deficiency type gastric cancer.