医用臭氧疗法治疗卒中后抑郁患者的临床疗效评价

Evaluation of curative effect of medical ozone in the treatment of post-stroke depression

目的:探讨医用臭氧治疗卒中后抑郁(PSD)的临床疗效。方法:2018年1月-2019年12月收治PSD患者120例,随机分为两组。两组均给予常规治疗;试验组增加医用臭氧治疗,随访1个月。比较两组临床疗效、血清超敏C反应蛋白(hs-CRP)水平及Hamilton抑郁量表(HAMD)评分;分析hs-CRP与HAMD之间的相关性。结果:治疗2周后,试验组血清hs-CRP水平及HAMD评分均低于对照组,差异有统计学意义(P<0.05);hs-CRP水平与HAMD评分呈正相关。随访1个月,试验组临床疗效优于对照组,差异有统计学意义(P<0.05)。结论:医用臭氧疗法可明显降低PSD患者hs-CRP水平,降低HAMD评分,可能通过减轻炎性反应机制,提高治疗有效率,为PSD的早期治疗提供新方法。

Objective:To investigate the clinical efficacy of medical ozone in the treatment of post-stroke depression(PSD).Methods:From January 2018 to December 2019,120 cases of PSD patients were enrolled,they were randomly divided into two groups.Both groups were given conventional treatment,while the experimental group added medical ozone treatment with following up for 1 month.The clinical efficacy,serum hs-CRP level and HAMD scale score of the two groups were compared.The correlation between hs-CRP and HAMD scale score was analyzed.Results:After 2 weeks of treatment,the serum hs-CRP level and HAMD scale score of the experimental group were significantly lower than those of the control group,the differences were statistically significant(P<0.05).hs-CRP level was positively correlated with HAMD scale score.After 1 month's followed-up,the clinical efficacy of the experimental group was significantly better than that of the control group,the difference was statistically significant(P<0.05).Conclusion:Medical ozone therapy can significantly reduce the hs-CRP content and HAMD scale score of PSD patients.It may provide a new method for early treatment of PSD by reducing the mechanism of inflammatory reaction and improve the effective rate of treatment.