吲哚布芬片在难治性肾病综合征治疗中的应用价值

Practical value of indobufen tablets in the treatment of refractory nephrotic syndrome

目的探讨在难治性肾病综合征的临床治疗中使用吲哚布芬片的临床价值。方法80例难治性肾病综合征患者,根据随机数字表法分为实验组和对照组,每组40例。对照组使用常规药物治疗,实验组进行吲哚布芬片治疗。比较两组患者治疗效果、治疗前后的肾功能指标(血肌酐、血尿素氮)和炎症因子[C反应蛋白(CRP)、肿瘤坏死因子(TNF)、白细胞介素(IL)]、不良反应发生情况。结果实验组治疗总有效率95.00%高于对照组的80.00%,不良反应发生率7.50%低于对照组25.50%,差异均具有统计学意义(P<0.05)。治疗后,两组血肌酐、血尿素氮水平均较治疗前有所改善,且实验组血尿素氮水平(7.21±1.35)mmol/L低于对照组的(10.52±2.17)mmol/L,差异均具有统计学意义(P<0.05)。两组患者治疗后血肌酐水平比较,差异无统计学意义(P>0.05)。治疗后,两组患者CRP、TNF、IL水平均较治疗前有所改善,且实验组患者CRP(3.96±0.83)mg/L、TNF(18.42±2.54)ng/L、IL(9.13±1.17)ng/L均低于对照组的(5.76±1.13)mg/L、(24.51±2.32)ng/L、(13.52±1.84)ng/L,差异均具有统计学意义(P<0.05)。结论吲哚布芬具有独特抗血小板作用和抗凝作用,且具有选择性、可逆性、多途径。在在难治性肾病综合征患者治疗中使用吲哚布芬片,效果可靠,安全性更好,胃肠道反应、出血等少,明显优于传统的抗血小板药物,更能起到良好的促进作用,值得在临床治疗中广泛使用。

Objective To discuss and analyze the clinical value of indobufen tablets in the treatment of refractory nephrotic syndrome.Methods A total of 80 patients with refractory nephrotic syndrome were divided into experimental group and control group according to random numerical table,with 40 cases in each group.The control group was treated with conventional drugs,and the experimental group was treated with indobufen tablets.The therapeutic effect,renal function indexes(serum creatinine,blood urea nitrogen),inflammatory factors[C-reactive protein(CRP),tumor necrosis factor(TNF),interleukin(IL)]before and after treatm ent and occurrence of adverse reactions were compared between the two groups.Results The total effective rate of treatment of the experimental group was 95.00%,which was higher than 80.00%of the control group,and incidence of adverse reactions 7.50%was lower than 25.50%of the control group,and the difference was statistically significant(P<0.05).After treatment,the serum creatinine,blood urea nitrogen of the two groups were improved compared with those before treatment,and blood urea nitrogen(7.21±1.35)mmol/L of the experimental group was lower than(10.52±2.17)mmol/L of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in serum creatinine after treatment between the two groups(P>0.05).After treatm ent,the levels of CRP,TNF and IL of the two groups were improved compared with those before treatment,and CRP(3.96±0.83)mg/L,TNF(18.42±2.54)ng/L,IL(9.13±1.17)ng/L of the experimental group were lower than(5.76±1.13)mg/L,(24.51±2.32)ng/L and(13.52±1.84)ng/L of the control group,and the difference was statistically significant(P<0.05).Conclusion Indobufen has unique antiplatelet and anticoagulant effects,and is selective,reversible,and multi-pathway.Indobufen tablets has reliable effects in the treatment of refractory nephrotic syndrome with higher safety,less gastrointestinal reactions and bleeding,which are significantly better than traditional antiplatelet drugs,and can perform better promotive effect.It is worthy of widely application in clinical treatment.