氟比洛芬酯在腔镜腹股沟疝修补术加速康复外科中的应用

Application of flurbiprofen axetil in fast track surgery of laparoscopic inguinal hernia repair

目的研究氟比洛芬酯在腔镜腹股沟疝修补术患者加速康复外科中的应用效果。方法90例行腔镜腹股沟疝修补术的患者为研究对象,随机分成A、B、C三组,各30例。A组于麻醉前15min静脉注射5ml(50mg)氟比洛芬酯注射液,B组于术后疼痛时静脉注射5ml(50mg)氟比洛芬酯注射液,C组于麻醉前15min静脉注射5ml生理盐水。比较三组患者的性别、年龄、术后出血量、肛门排气、住院时间;术后不良反应发生情况,不同时间的视觉模拟评分法(VAS)评分。结果三组患者的性别、年龄比较,差异无统计学意义(P>0.05);A组及B组的术后出血量少于C组、术后肛门排气时间短于C组,A组的住院时间短于B组及C组,差异均具有统计学意义(P<0.05);A组与B组的术后出血量、术后肛门排气时间,B组与C组的住院时间比较,差异均无统计学意义(P>0.05)。A、B、C三组患者的不良反应发生率分部为6.7%、3.3%、6.7%,比较差异无统计学意义(P>0.05)。三组患者给药前、术后24h的VAS评分比较,差异无统计学意义(P>0.05)。术后1、4h,A组患者的VAS评分低于B组及C组,B组患者的VAS评分低于C组,差异均具有统计学意义(P<0.05)。术后12h,A组患者的VAS评分低于B组及C组,差异具有统计学意义(P<0.05);B组与C组的VAS评分比较,差异无统计学意义(P>0.05)。结论氟比洛芬酯超前镇痛在腔镜腹股沟疝修补术加速康复外科中具有一定的医疗效应。

Objective To study the practical effect of flurbiprofen axetil in fast track surgery of laparoscopic inguinal hernia repair.Methods A total of 90 patients with laparoscopic inguinal hernia repair as study subjects were randomly divided into group A,group B and group C,with 30 cases in each group.Group A was injected with 5 ml(50 mg)flurbiprofen axetil 15 min before anesthesia,group B was injected with 5 ml(50 mg)flurbiprofen axetil injection during postoperative pain,and group C was injected with 5 ml normal saline 15 min before anesthesia.The gender,age,postoperative blood loss,anal exhaust time,hospitalization time,occurrence of postoperative adverse reactions,visual analogue scale(VAS)score at different time of the three groups were compared.Results There was no statistically significant difference in gender and age among the three groups(P>0.05).The postoperative blood loss of group A and group B were less than that of group C,anal exhaust time was shorter than that of group C,and the hospitalization time of group A was shorter than that of group B.The difference was statistically significant(P<0.05).There was no statistically significant difference in postoperative blood loss and anal anal exhaust time between group A and group B,and the hospitalization time between group B and group C(P>0.05).The incidence of adverse reactions of group A,group B and group C were 6.7%,3.3%and 6.7%,and the difference was not statistically significant(P>0.05).There was no statistically significant difference in VAS score before medication and 24 h after the surgery in three groups(P>0.05).1 and 4 h after the surgery,VAS score of group A was lower than that of group B and group C,and VAS score of group B was lower than that of group C,and the difference was statistically significant(P<0.05).12 h after the surgery,VAS score of group A was lower than that of group B and group C,and the difference was statistically significant(P<0.05).There was no statistically significant difference in VAS score between group B and group C(P>0.05).Conclusion Flurbiprofen axetil has certain medical effect in the fast track surgery of laparoscopic inguinal hernia repair.