鸦胆子油乳联合GP方案治疗非小细胞肺癌淋巴结转移的效果

Effect of brucea javanica oil emulsion combined with GP regimen in the treatment of lymph node metastasis of non-small cell lung cancer

目的探讨鸦胆子油乳联合吉西他滨+顺铂(GP)方案治疗非小细胞肺癌淋巴结转移的效果。方法 84例非小细胞肺癌淋巴结转移患者,随机分为观察组与对照组,各42例。对照组单用GP方案治疗,观察组在对照组基础上使用鸦胆子油乳治疗。对比两组的近期疗效、免疫功能指标变化、肿瘤标志物水平变化。结果观察组有效率为69.05%,高于对照组的47.62%,差异有统计学意义(P<0.05)。治疗后,观察组CD3+、CD4+、CD4+/CD8+高于对照组, CD8+低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组癌胚抗原(CEA)、鳞状上皮细胞癌抗原(SCC)、表皮生长因子受体(EGFR)水平分别为(6.79±3.14)、(4.36±2.01)、(15.84±3.09)ng/ml,低于对照组的(9.03±3.24)、(6.18±2.38)、(18.79±3.85)ng/ml,差异有统计学意义(P<0.05)。结论鸦胆子油乳联合GP方案治疗非小细胞肺癌淋巴结转移的效果显著,能增强肿瘤抑制效果,延缓病情进展,调节机体细胞免疫功能,具有积极的临床意义。

Objective To discuss the effect of brucea javanica oil emulsion combined with GP regimen in the treatment of lymph node metastasis of non-small cell lung cancer. Methods A total of 84 patients with lymph node metastasis of non-small cell lung cancer were randomly divided into observation group and control group, with 42 cases in each group. The control group was treated with GP regimen, and the observation group was treated with brucea javanica oil emulsion on the basis of the control group. The short-term efficacy, immune function indicators and tumor marker levels changes were compared between the two groups. Results The effective rate of the observation group was 69.05%, which was higher than 47.62% of the control group, and the difference was statistically significant(P<0.05). After treatment, CD3+, CD4+ and CD4+/CD8+ of the observation group were higher than those of the control group, and CD8+ was lower than the control group, and the difference was statistically significant(P<0.05). After treatment, carcinoembryonic antigen(CEA), squamous cell carcinoma(SCC) and epidermal growth factor receptor(EGFR) of the observation group were(6.79±3.14),(4.36±2.01) and(15.84±3.09) ng/ml, which were lower than(9.03±3.24),(6.18±2.38) and(18.79±3.85) ng/ml of the control group, and the difference was statistically significant(P<0.05). Conclusion Brucea javanica oil emulsion combined with GP regimen shows remarkable effect in the treatment of lymph node metastasis of non-small cell lung cancer, which can enhance the tumor suppressive effect, delay the progression of the disease, and regulate the body’s cellular immune function, which has positive clinical significance.