羟苯磺酸钙对糖尿病视网膜病变患者视力的影响

Effect of calcium dobesilate on visual acuity in patients with diabetic retinopathy

目的研究羟苯磺酸钙对糖尿病视网膜病变患者视力的影响。方法 820例(1491只眼)糖尿病视网膜病变的患者,采用随机数字表法将患者分为对照组(410例, 740只眼)和观察组(410例,751只眼)。对照组采用复方血栓通胶囊治疗,观察组在对照组基础上服用羟苯磺酸钙胶囊。比较两组治疗后的临床疗效,治疗前后最小分辨角对数(logMAR)视力、出血斑面积及血管瘤体积,血清肿瘤坏死因子-α(TNF-α)和促生长因子-1(IGF-1)水平。结果观察组患者的临床总有效率为84.02%,高于对照组的59.19%,差异有统计学意义(P<0.05)。治疗后,两组患者的logMAR视力、出血斑面积及血管瘤体积均优于治疗前,且观察组logMAR视力(0.37±0.05)低于对照组的(0.49±0.07),出血斑面积(1.23±0.35)mm^2及血管瘤体积(11.03±2.20)μm^3小于对照组的(1.90±0.39)mm^2、(15.01±2.53)μm^3,差异具统计学意义(P<0.05)。治疗后两组患者血清TNF-α、IGF-1水平均较治疗前降低,且观察组血清TNF-α(21.43±3.56)ng/L、IGF-1(90.08±20.40)ng/ml低于对照组的(34.08±5.62)ng/L、(121.64±29.37)ng/ml,差异有统计学意义(P<0.05)。结论羟苯磺酸钙能够有效缓解糖尿病视网膜病变患者的临床症状,提高患者的视力水平,抑制炎症反应,且疗效确切。

Objective To study the effect of calcium dobesilate on visual acuity in patients with diabetic retinopathy. Methods A total of 820 patients(1491 eyes) with diabetic retinopathy were divided into a control group(410 cases, 740 eyes) and observation group(410 cases, 751 eyes) according to random numerical table. The control group was treated with Compound Xueshuantong Capsules, and the observation group was treated with calcium dobesilate capsule based on the control group. The clinical efficacy after treatment, logMAR visual acuity, hemorrhagic plaque area, hemangioma volume, and serum tumor necrosis factor-α(TNF-α) and insulinlike growth factor-1(IGF-1) levels before and after treatment were compared between the two groups. Results The total clinical effective rate of the observation group was 84.02%, which was higher than 59.19% of the control group, and the difference was statistically significant(P<0.05). After treatment, the logMAR visual acuity, hemorrhagic plaque area, hemangioma volume of the two groups were better than those before treatment;logMAR visual acuity(0.37±0.05) of the observation group was lower than(0.49±0.07) of the control group, hemorrhagic plaque area(1.23±0.35) mm2 and hemangioma volume(11.03±2.20) μm^3 were less than(1.90±0.39) mm^2 and(15.01±2.53) μm^3 of the control group, and the difference was statistically significant(P<0.05). After treatment, TNF-α and IGF-1 of the two groups were lower than those before treatment, and TNF-α(21.43±3.56) ng/L and IGF-1(90.08±20.40) ng/ml of the observation group were lower than(34.08±5.62) ng/L and(121.64± 29.37) ng/ml of the control group, and the difference was statistically significant(P<0.05). Conclusion Calcium dobesilate can effectively relieve the clinical symptoms, improve the visual acuity and inhibit the inflammatory reaction in patients with diabetic r etinopathy.