保留生育功能术对宫颈癌患者生育功能的影响

The effect of fertility preservation surgery on fertility function of patients with cervical cancer

目的探讨保留生育功能手术在早期宫颈癌治疗中的效果。方法根据手术方案的不同将106例早期宫颈癌患者分为观察组(n=46)和对照组(n=60),对照组患者行常规宫颈癌根治术,观察组患者行保留生育功能手术。比较两组患者的手术相关指标、手术前后的生活质量、术后并发症发生情况和复发情况;记录观察组患者的术后妊娠情况。结果两组患者的手术时间、术中出血量、淋巴结清扫数目、自主排尿时间和肠道功能恢复时间比较,差异均无统计学意义(P> 0.05)。术后,观察组患者的简明健康状况调查问卷(SF-36)评分明显高于对照组患者,差异有统计学意义(P<0.01)。两组患者的术后并发症发生率比较,差异无统计学意义(P>0.05)。截至随访结束,两组患者的复发率均为0%;观察组患者的术后成功妊娠率为76.09%(35/46)。结论保留生育功能手术治疗早期宫颈癌具有较好的效果,能够保留患者的生育功能,改善患者的生活质量,且术后妊娠率较满意。

Objective To explore the effect of fertility preservation surgery in the treatment of early cervical cancer.Method A total of 106 cases patients of early cervical cancer were selected and divided into the observation group(n=46)and control group(n=60)according to the surgery regimens.The control group was treated with conventional radical surgery for cervical cancer while the observation group was treated with fertility preservation surgery.The relevant indicators in surgery,the quality of life before and after the surgery,and the occurrence of postoperative complications and recurrence of the two groups were compared.The postoperative pregnancy of the observation group was also recorded.Result There was no statistically significant difference in the surgery time,intraoperative blood loss volume,number of lymph node dissections,autonomous urination time and intestinal function recovery time between the two groups(P>0.05).After the surgery,the the medical outcomes study 36-item short form health survey(SF-36)score of the observation group was significantly higher than that of the control group,and the difference was statistically significant(P<0.01).There was no statistically significant difference in the incidence rate of postoperative complications between the two groups(P>0.05).By the end of the follow-up,the recurrence rate of the two groups was 0%and the successful pregnancy rate of the observation group was 76.09%(35/46).Conclusion Fertility preservation surgery for early cervical cancer shows a promising effect,which can preserve the patient’s fertility function,improve the patient’s quality of life,and meet the satisfactory rate of the postoperative pregnancy.