摘要
激肽释放酶-激肽系统(kallikrein-kinin system,KKS)是哺乳动物机体内重要的生理调控系统,其通过激肽释放酶裂解激肽原产生激肽,后者与体内激肽受体结合并通过下游多条信号通路发挥生物学效应。KKS与缺血性脑卒中(ischemic stroke,IS)的发生、发展紧密相连,参与调控细胞凋亡、氧化应激和炎症反应以及血管新生等。此外,作为IS病因、病理的重要方面,血栓性炎症的发生、发展亦涉及KKS。本文基于KKS,对其在IS疾病进程中的作用相关研究进展进行综述,以期为IS治疗药物的研发提供新的干预靶点和治疗策略。
The kallikrein-kinin system (KKS) is an important physiological regulation system of the mammals,in which kinin is produced from kininogen via kallikrein and binds to its receptors to exert various biological effects through downstream multiple signaling pathways.KKS is closely associated with the pathogenesis of ischemic stroke (IS),being involved in modulating apoptosis,oxidative stress,inflammation as well as neovascularization.Moreover,as the important aspect of the pathogenesis of IS,the thrombo inflammation occur and progress requiring the involvement of KKS.Based on the KKS,we reviewed the research progress of the role of KKS in the disease progression of IS in order to provide the new intervening target and strategy.
作者
岳佳新
王志勇
YUE Jia-xin;WANG Zhi-yong(Shanghai Institute of Pharmaceutical Industry,China State Institute of Pharmaceutical Industry,Shanghai 200040,China)
出处
《世界临床药物》
CAS
2020年第11期900-904,共5页
World Clinical Drug
基金
上海市生物物质成药性评价专业技术服务平台(15DZ2291700)。
