阿奇霉素静脉滴注时间对肺炎支原体肺炎患儿治疗效果及安全性的影响

Effect of azithromycin administration time on therapeutic effect and safety of children with Mycoplasma pneumoniae pneumonia

目的观察阿奇霉素静脉滴注时间对肺炎支原体肺炎患儿治疗效果及安全性的影响。方法选取2017年10月-2018年10月曲靖市妇幼保健院收治的肺炎支原体肺炎患儿100例,随机抽签分为观察组和对照组,每组50例。2组患儿均予阿奇霉素注射液治疗,观察组静脉滴注持续时间为2 h,对照组静脉滴注持续时间为4 h,均治疗1周。比较2组患儿治疗后平均退热时间、症状(咳嗽、呼吸困难、肺部啰音)缓解时间、炎性指标[白细胞、中性粒细胞比例、C反应蛋白(CRP)值]恢复情况、不良反应(恶心、呕吐、头晕及腹泻)发生情况及患儿不良情绪改善情况。结果观察组患儿平均退热时间(1.83±1.11)d,短于对照组的(4.54±2.61)d(t=6.756,P=0.000);观察组患儿咳嗽、呼吸困难、肺部啰音缓解时间均短于对照组(P<0.01);治疗后,2组炎性指标均较治疗前改善(P<0.01),但2组组间差异无统计学意义(P>0.05);观察组不良反应发生率为4.00%,低于对照组的20.00%(χ^2=6.061,P=0.014);治疗后2组患儿不良情绪评分均有所降低,且观察组降低幅度大于对照组(P<0.01)。结论控制阿奇霉素静脉滴注时间在2 h情况下,可缩短肺炎支原体肺炎患儿康复时间,降低不良反应发生风险,改善患儿不良情绪,值得临床推广应用。

Objective To observe the effect of azithromycin intravenous infusion time on the treatment effect and safety of children with Mycoplasma pneumoniae pneumonia.Method One hundred children with Mycoplasma pneumoniae pneumonia in Qujing maternal and child health hospital from October 2017 to October 2018 were selected and randomly divided into observation group and control group,with 50 cases in each group.Both groups were treated with azithromycin injection.The duration of intravenous drip in the observation group was 2 h,while that in the control group was 4 h.Both groups were treated for 1 week.After treatment,the antipyretic time,symptoms(cough,dyspnea,lung rales)relief time,inflammatory indicators(white blood cells,neutrophil ratio,CRP value)recovery,adverse reactions(nausea,vomiting,dizziness and diarrhea)and the improvement of adverse emotions were compared between the two groups.Results The average defervescence time of observation group was(1.83±1.11)d,which was shorter than that of control group(4.54±2.61)d(t=6.756,P=0.000);The remission time of cough,dyspnea and pulmonary rales in the observation group was shorter than that in the control group(P<0.01);After treatment,the inflammatory indexes of the two groups were improved compared with those before treatment(P<0.01),but there was no significant difference between the two groups(P>0.05);The incidence of adverse reactions in the observation group was 4.00%,lower than 20.00%in the control group(χ^2=6.061,P=0.014);After treatment,the scores of adverse emotions in the two groups were decreased,and the decrease in the observation group was greater than that in the control group(P<0.01).Conclusion If the intravenous infusion time of azithromycin is controlled within2 hours,the recovery time of children with Mycoplasma pneumoniae pneumonia can be shortened,the risk of adverse reactions can be reduced,and the adverse emotions of children can be improved,which is worthy of clinical application.