晚期肺癌患者生命质量及其影响因素分析

Analysis of the quality of life of patients with advanced lung cancer and its influencing factors

目的:探讨晚期肺癌患者的生命质量及其相关影响因素。方法:选择2017年6月至2019年6月在山西省肿瘤医院住院的晚期肺癌患者220例,采用欧洲癌症治疗研究组织(EORTC)生命质量测定量表(QLQ-C30)和肺癌患者生命质量量表(QLQ-LC13)评估患者生命质量。结合患者的临床病理资料,采用多元线性回归法对影响晚期肺癌患者生命质量的因素进行分析。结果:共发放问卷220份,收回有效问卷184份(83.6%),其中男性102例(55.4%),女性82例(44.6%)。在QLQ-C30的5个功能领域中,社会功能领域得分较低[(60.2±11.8)分],认知功能领域得分较高[(78.5±13.4)分];在3个症状领域中,疼痛得分较高[(36.8±10.3)分];在6个单一条目中,食欲缺乏较为严重[(58.5±10.5)分]。在QLQ-LC13的10个症状领域中,气促、咳嗽症状较为突出[(34.6±9.5)分、(33.6±6.8)分]。女性、年龄大、子女少、转移器官数目多、伴有其他疾病及接受化疗患者的生命质量较差(均 P<0.05),未发现吸烟状况及职业、文化程度与晚期肺癌患者生命质量有相关性(均 P>0.05)。 结论:晚期肺癌患者性别、年龄、子女数、转移器官数目、是否伴有其他疾病、治疗方式与其生命质量密切相关,针对性地采取干预措施,有利于改善患者生命质量。

Objective To explore the quality of life of patients with advanced lung cancer and its influencing factors.Methods A total of 220 patients with advanced lung cancer in Shanxi Provincial Cancer Hospital from June 2017 to June 2019 were selected.The European Organization for Research and Treatment of Cancer(EORTC)Quality of Life Questionnaire Core-30(QLQ-C30)and Quality and Life Questionnaire of Lung Cancer(QLQ-LC13)were used to evaluate the quality of life of patients.Combined with the clinicopathological data of the patients,multiple linear regression method was used to analyze the factors affecting the quality of life of patients with advanced lung cancer.Results A total of 220 questionnaires were issued,and 184(83.6%)valid questionnaires were returned.There were 102 cases(55.4%)of male and 82 cases(44.6%)of female.Among the 5 functional areas of QLQ-C30,the score of social function was low[(60.2±11.8)points],and the score of cognitive function was high[(78.5±13.4)points];among the 3 symptom areas,the score of pain was high[(36.8±10.3)points];among the 6 single items,the lack of appetite was more serious[(58.5±10.5)points].Among the 10 symptom areas of QLQ-LC13,shortness of breath and cough were more prominent[(34.6±9.5)points and(33.6±6.8)points].The quality of life of female patients,patients with older age,patients with fewer children,patients with more organ metastases,patients with other diseases and patients with chemotherapy was poor(all P<0.05),while there was no correlation between smoking status,occupation and education level and the quality of life of advanced lung cancer patients(all P>0.05).Conclusions The quality of life of advanced lung cancer patients is closely related to gender,age,the number of children,the number of metastatic organs,with or without diseases and treatment methods.Targeted intervention measures are helpful to improve the quality of life of patients.