阿莫西林克拉维酸钾干混悬剂联合硫酸沙丁胺醇对儿童支气管哮喘合并肺部感染的临床疗效

Clinical efficacy of amoxicillin-clavulanate potassium dry suspension combined with salbutamol sulfate in children with bronchial asthma complicated with pulmonary infection

目的探讨分析阿莫西林克拉维酸钾干混悬剂联合硫酸沙丁胺醇对儿童支气管哮喘合并肺部感染的临床疗效。方法选择2017年3月-2018年3月儋州市人民医院收治的支气管哮喘合并肺部感染患儿135例,随机分为观察组69例、对照组66例,对照组在常规治疗基础上给予硫酸沙丁胺醇治疗,观察组在对照组基础上给予阿莫西林克拉维酸钾干混悬剂治疗。比较两组临床疗效、临床症状及体征消失时间、住院时间、治疗前后氧化应激指标以及炎症指标改善情况、不良反应和随访复发情况。结果观察组患儿治疗临床疗效总有效率显著高于对照组,差异有统计学意义(χ2=4.524,P=0.033)。治疗后观察组患儿临床症状、体征改善时间以及住院时间显著低于对照组,差异有统计学意义(P<0.05)。两组治疗后超氧化物歧化酶(SOD)水平显著升高,丙二醛(MDA)水平显著降低,且治疗后观察组患儿SOD显著高于对照组,MDA显著低于对照组,差异均有统计学意义(P<0.05)。治疗后两组血清炎症因子肿瘤坏死因子-α(TNF-α)、白介素-4(IL-4)、白介素-8(IL-8)水平较治疗前显著降低,且治疗后观察组患者血清TNF-α、IL-4、IL-8水平均显著低于对照组,差异均有统计学意义(P<0.05)。观察组随访复发率显著低于对照组,差异有统计学意义(P<0.05)。结论阿莫西林克拉维酸钾联合硫酸沙丁胺醇治疗儿童支气管哮喘合并肺部感染临床疗效显著,可快速改善患儿临床症状,降低患儿治疗后复发率,且安全有效,值得推广。

Objective To investigate and analyze the clinical efficacy of amoxicillin-clavulanate potassium dry suspension combined with salbutamol sulfate in children with bronchial asthma complicated with pulmonary infection.Methods 135 children with bronchial asthma complicated with pulmonary infection admitted to our hospital from March 2017 to March2018 were randomly divided into observation group(69 cases) and control group(66 cases).The control group was treated with salbutamol sulfate on the basis of routine treatment,while the observation group was treated with amoxicillinclavulanate potassium dry suspension on the basis of the control group.The clinical efficacy,disappearance time of clinical symptoms and signs,hospitalization time,oxidative stress index before and after treatment,improvement of inflammation index,non-response and recurrence of follow-up were compared between the two groups.Results The clinical efficacy of the observation group was significantly higher than that of the control group(χ~2=4.524,P=0.033).The improvement time of clinical symptoms,signs and hospitalization time in the observation group were significantly lower than those in the control group(P<0.05).After treatment,the levels of superoxide dismutase(SOD) was significantly increased and malondialdehyde(MDA) was significantly decreased(P<0.05).After treatment,SOD in the observation group was significantly higher than that in the control group,and MDA in the observation group was significantly lower than that in the control group(P<0.05).After treatment,the levels of serum tumor necrosis factor-α(TNF-α),interleukin-4(IL-4) and interleukin-8(IL-8) in the two groups were significantly lower than those before treatment,and the levels of serum TNF-α,IL-4 and IL-8 in the observation group were significantly lower than those in the control group(P<0.05).The recurrence rate in the observation group was significantly lower than that in the control group(P<0.05).Conclusions Amoxicillin and clavulanate potassium combined with salbutamol sulfate in the treatment of children with bronchial asthma complicated with pulmonary infection had significant clinical efficacy.It could rapidly improve the clinical symptoms of children with asthma and reduce the recurrence rate after treatment.The clinical treatment was safe,effective,and worthy of promotion.