女性绝经状态与同型半胱氨酸和纤维蛋白原的相关性分析

Correlation between homocysteine,fibrinogen and female menopausal status

目的探讨女性绝经状态与同型半胱氨酸(Hcy)、纤维蛋白原(FIB)的关系。方法回顾性分析2017年1月-2019年1月于该院妇科内分泌门诊就诊的547例围绝经期患者的病历资料,其中绝经过渡期女性326例,绝经期女性221例,未使用过绝经激素补充治疗,测定Hcy、FIB水平,统计分析绝经状态与Hcy、FIB的相关性。结果绝经过渡期和绝经期女性血Hcy水平分别为(8.26±4.75)μmol/L、(9.37±3.55)μmol/L,血FIB水平分别为(2.79±0.67)g/L、(2.94±0.70)g/L。绝经过渡期血Hcy、FIB水平低于绝经期(P<0.05)。单因素分析显示,年龄、体质指数(BMI)、Hcy、FIB、C-反应蛋白(CRP)水平与绝经状态显著相关(P<0.05)。在校正年龄、BMI等因素影响后,血Hcy、CRP与绝经状态显著相关(P<0.05),FIB与绝经状态无关(P>0.05)。结论女性绝经状态与Hcy、FIB、CRP有相关性,但FIB不是绝经状态的独立影响因素。

Objective To explore the relationship between female menopausal status and homocysteine(Hcy),fibrinogen(FIB).Methods A retrospective analysis was performed on 547 patients(326 patients were in menopausal transition period and 221 patients were postmenopausal period)who visited the gynecological endocrine outpatient department in our hospital from January 2017 to January 2019.The levels of Hcy and FIB were measured,and statistically analyzed the correlation between menopause status and Hcy,FIB.Results The Hcy levels in menopausal transitional and menopausal women were(8.26±4.75)μmol/L,(9.37±3.55)μmol/L,and FIB levels were(2.79±0.67)g/L,(2.94±0.70)g/L,respectively.The results showed that Hcy and FIB levels in the menopausal transition period were lower than those in the menopausal period(P<0.05).Univariate analysis showed that age,body mass index(BMI),Hcy,FIB,and Creactive protein(CRP)levels were significantly associated with menopausal status(P<0.05).After adjusting for age,BMI and other factors,Hcy and CRP were significantly associated with menopausal status(P<0.05),however FIB was not associated with menopausal status(P>0.05).Conclusion The menopausal status of women was correlated with Hcy,FIB and CRP,but FIB is not an independent influencing factor in menopausal status.