右美托咪定联合羟考酮在无痛人工流产术中的临床观察

Clinical observation of dexmedetomidine combined with oxycodone in painless induced abortion

目的探讨右美托咪定联合羟考酮在无痛人工流产术中的安全性和有效性。方法60例择期行无痛人工流产术患者,根据数字随机表法将患者分为两组,每组30例。Pro组接受右美托咪定与羟考酮,Dex组接受丙泊酚与羟考酮。记录手术时间、麻醉苏醒时间;记录入室(T1)、麻醉诱导完成(T2)、扩张宫颈(T3)以及苏醒即刻(T4)的心率(HR)与平均动脉压(MAP);记录围术期不良事件发生情况。结果与Pro组比较,Dex组在T2、T3以及T4时间点的HR均降低,差异均有统计学意义(均P<0.05);而在T2时间点Dex组的MAP高于Pro组(P<0.05)。与T1时间点比较,Dex组的HR在T2、T3以及T4时间点均降低,差异均有统计学意义(均P<0.05);Pro组T2时的MAP比T1时降低,差异均有统计学意义(均P<0.05)。与Pro组比较,Dex组的苏醒时间明显减少(P<0.05)。与Pro组比较,Dex组患者注射痛和呼吸抑制的发生率明显减少(P<0.05)。结论右美托咪定联合羟考酮比丙泊酚联合羟考酮在人工无痛流产术中具有更少副作用,可安全有效的用于无痛人工流产术。

Objective To investigate the safety and efficacy of dexmedetomidine combined with oxycodone in painless induced abortion.Methods 60 patientsundergoingelective painless induced abortion were randomly divided into 2 groups according to the random number table,each group containing 30 patients.Group Pro received dexmedetomidine and oxycodone,while the group Dex received propofol and oxycodone.Record the operation time and anesthesia recovery time;Heart rate(HR)and average arterial pressure(MAP)were recorded for entry(T1),completion of anesthesia induction(T2),dilation of the cervical(T3),and immediate awakening(T4).Perioperative adverse events were alsorecorded.Results Compared with the group Pro,the HR at the time points of T2,T3 and T4 in the group Dex was reduced(all P<0.05).The MAP of group Dex at T2 time point was higher than that of group Pro(P<0.05).Compared with the time point of T1,HR in the group Dex was reduced at the time points of T2,T3 and T4(all P<0.05).The MAP of group Pro at T2 was lower than that at T1(all P<0.05).Compared with the group Pro,the recovery time of group Dex was significantly reduced(P<0.05).Compared with the group Pro,the incidence of injection pain and respiratory depression was significantly reduced in the group Dex(P<0.05).Conclusion Compare with propofol combined with oxycodone,Dexmedetomidine combined with oxycodone was fewer side effects,and could be used safely and effectively in painless abortion.