期刊文献+

醋酸泼尼松联合阿维A治疗溃疡性扁平苔藓一例

A case of ulcerative lichen planus successfully treated by systemic prednisone combined with acitretin
下载PDF
导出
摘要 56岁男性患者,右下腹出现黑褐色斑片伴瘙痒7年余,反复破溃伴疼痛4年。皮肤科情况:腰骶部及右下腹部分别可见两处面积约6 cm×8 cm大小紫红色斑片,皮损边缘呈黑褐色至蓝紫灰色,右下腹皮损中央表皮萎缩变薄、可见一2cm×4.5cm大小境界清楚的表浅溃疡,基底红润,表面较多血性分泌物。溃疡边缘组织病理示:角化亢进,表皮灶状海绵水肿,灶状基底细胞液化,真皮浅层及血管周围淋巴细胞浸润,散在噬黑素细胞。诊断:溃疡性扁平苔藓。治疗:口服醋酸泼尼松起始剂量30 mg、阿维A胶囊起始剂量20 mg,每日分次口服。治疗26周后,溃疡愈合。外用吡美莫司乳膏维持治疗3个月,随访1年无复发。 A 56-year-old man presented with a 7-year history of a pruritic dark brown patch on his right lower abdomen as well as a recurrent painful ulcer on the patch for 4 years. Physical examination: there were two violaceous reddish patches of 6 cm×8 cm in size located on the lumbosacral region and right lower abdomen respectively, the edge of the lesions was hyperpigmented, a well defined ulcer of 2 cm×4.5 cm in size were located on the surface of the right lower abdomen lesion, the base of ulcer was ruddy with some bloody secretions. Mouth and other mucosas were not involved. Histopathological examination showed hyperkeratosis, focal spongiosis of epidermis, liquefaction of focal basal cells, infiltration of lymphocytes in the superficial dermis and around blood vessels, with scattered melanophagocytes. The diagnosis of ulcerative lichen planus was established. The patient was treated by prednisone(initial dose of 30 mg daily) combined with acitretin(initial dose of 20 mg daily) for 26 weeks, and the ulcers resolved gradually, followed by pimenimus cream maintenance therapy for 3-month. There was no recurrence after one year follow-up.
作者 周俐宏 李邻峰 ZHOU Li-hong;LI Lin-feng(Beiing Friendship Hospital,Captial Medical University,100050 Beijing,China)
出处 《实用皮肤病学杂志》 2020年第5期318-320,共3页 Journal of Practical Dermatology
关键词 扁平苔藓 溃疡性 泼尼松 阿维A Lichen planus,ulcerative Prednisone Acitretin
  • 相关文献

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部