芍药汤加味治疗溃疡性结肠炎患者的疗效和作用机制

Effect and Mechanism of Shaoyao Decoction in the Treatment of Patients with Ulcerative Colitis

目的探讨芍药汤加味治疗溃疡性结肠炎患者的疗效及机制。方法选取2017年12月至2018年12月辽阳市中医院收治的98例溃疡性结肠炎患者作为研究对象,按随机数字表法分为观察组与对照组,各49例。观察组采用芍药汤加味治疗,对照组给予常规治疗,比较两组患者临床疗效、中医证候积分、结肠镜下黏膜评分、血清炎症介质。结果观察组治疗有效率为93.88%,对照组治疗有效率为79.59%,差异有统计学意义(P<0.05);治疗后,观察组患者中医证候积分、结肠镜下黏膜评分及血清肿瘤坏死因子-α(TNF-α)、白细胞介素-8(IL-8)水平低于对照组,差异有统计学意义(P<0.05)。结论芍药汤加味治疗溃疡性结肠炎疗效显著,可有效改善患者临床症状,促进溃疡修复和黏膜愈合,作用机制可能与下调血清TNF-α和IL-8水平有关。

Objective To explore the efficacy and mechanism of Shaoyao Decoction in the treatment of patients with ulcerative colitis(UC). Methods A total of 98 UC patients were selected as the research objects and were assigned into an observation group(49 cases) and a control group(49 cases) according to random number table method. The observation group was treated with Shaoyao Decoction, and the control group was given conventional treatment. Results The total effective rate of the observation group was 93.88% and that of the control group was 79.59%, the difference was statistically significant(P<0.05);after treatment, the scores of TCM syndromes, mucosal scores under colonoscopy, and serum tumor necrosis factor-α(TNF-α) and interleukin-8(IL-8) levels in the observation group were lower than those in the control group, and the differences were statistically significant(P<0.05). Conclusion The effect of Shaoyao Decoction on UC is significant. It can effectively improve the clinical symptoms of patients, promote ulcer repair and mucosal healing. The mechanism may be related to the down-regulation of serum TNF-α and IL-8 levels.