骨髓来源抑制性细胞在血液系统肿瘤中的研究进展

Progress of myeloid-derived suppressor cells in hematological tumors

骨髓来源抑制性细胞(MDSC)是一种能够调节免疫反应的未成熟髓样细胞的异质群体,它们在肿瘤的形成和进展中起着重要作用,在感染和炎性疾病中可抑制免疫反应。近年MDSC在肿瘤免疫学领域引起了广泛的关注,尤其是在实体肿瘤中,但MDSC在血液系统肿瘤中的研究知之甚少。文章就MDSC在血液系统肿瘤,包括多发性骨髓瘤(MM)、淋巴瘤、白血病和骨髓增生异常综合征(MDS)等中的特性、功能和相关临床研究进行总结,为血液系统肿瘤的治疗提供新思路。

Myeloid-derived suppressor cells(MDSC)are a heterogeneous population of immature myeloid cells that can regulate the immune response.They play an important role in the formation and progression of tumors and can suppress immune response in infections and inflammatory diseases.In recent years,MDSC have attracted a lot of attention in the field of tumor immunology,especially in solid tumors,but little is known about the role in hematological tumors.In this paper,the characteristics,functions and related clinical researches of MDSC in hematological tumors including multiple myeloma(MM),lymphoma,leukemia,and myelodysplastic syndrome(MDS)will be summarized to provide new ideas for the treatment of hematologic system tumors.