剪切波弹性成像在评估2型糖尿病肾功能正常者肾皮质硬度的价值

Value of Shear Wave Elastography Imaging in Evaluating Renal Cortical Stiffness of Patients with Type 2 Diabetes Mellitus without Diabetic Nephropathy

目的探讨肾功能正常的2型糖尿病患者与非糖尿病患者比较经剪切波弹性成像检查肾皮质硬度的变化。方法共收集100例研究对象,其中男性65例,女性35例,平均年龄为60.1±23.4岁,包括2型糖尿病肾功能正常患者50例,无2型糖尿病肾功能正常者50例,所有研究对象肾小球滤过率均正常。所有病例均记录常规病史及相关实验室检查,均进行肾脏常规超声检查及剪切波弹性成像检查。结果2型糖尿病组的血糖、糖化血红蛋白及尿素氮较对照组高(P<0.05)。两组肾脏大小比较,差异无统计学意义。2型糖尿病患者肾皮质厚度较高。剪切波弹性成像测得肾实质硬度值在2型糖尿病患者中显著升高(P<0.05)。结论剪切波弹性成像获得的肾皮质硬度值在肾功能正常的2型糖尿病患者中明显高于未患糖尿病者。肾皮质硬度测量可以作为2型糖尿病患者肾脏常规筛查的一部分,以指导临床治疗。

Objective To investigate the change of renal cortical stiffness(CS)obtained by SWE examination in type 2 diabetes mellitus(DM)patients with normal renal function compared to non DM patients.Methods A total of 100 patients,65 males,35 females and mean age 60.1±23.4 years.in the study,including 50 patients with type 2 DM and 50 patients without type 2 DM.The GFR value of all patients was normal.Routine history and laboratory examinations were performed.In addition to routine renal Ultrasonography(USG),CS obtained by SWE examination were measured.Results Patients with type 2 DM had higher blood glucose,blood urea nitrogen and HbA1 c levels(P<0.05).Renal length and width were similar between two groups with conventional renal USG.Renal cortical thickness was higher in patients with type 2 DM.CS values obtained with renal SWE were significantly higher in patients with type 2 DM(P<0.05).Conclusion Cortical stiffness value obtained by SWE is signifcantly higher in type 2 DM patients with normal renal function compared to patients without DM.CS measurement as part of routine examination of nephropathy in patients with type 2 DM is recommended to guide management and treatment.