妊娠期糖尿病患者补充维生素D3对T淋巴细胞亚群水平的影响分析

Analysis of the Effect of Vitamin D3 Supplementation on the Level of T Lymphocyte Subsets in Patients with Gestational Diabetes

目的通过给予妊娠期糖尿病(GDM)患者维生素D3干预,探究其对患者细胞免疫的影响。方法将该院2019年3月—2020年3月收治的104例GDM患者纳入研究中,基于乱数表法分成研究组和对照组;对照组实施常规治疗,研究组同时服用维生素D3制剂。测定两组FPG、25(OH)D水平,并测定T淋巴细胞亚群水平。结果治疗后研究组患者FPG(4.03±0.22)mmol/L水平较对照组有所降低、25(OH)D水平(84.01±11.62)nmol/L有所升高,组间比较差异有统计学意义(P<0.05);治疗后,与对照组对比,研究组患者CD8+细胞(30.25±4.83)%明显降低,其他细胞免疫因子比较均有所升高,组间比较差异有统计学意义(P<0.05);治疗后研究组相比于对照组,患者体内Th1、Th1/Th2细胞均差异有统计学意义(P<0.05)。结论补充维生素D3对于GDM患者而言可改善其血糖水平,维持体内细胞免疫因子水平,对免疫机能有一定保护作用。

Objective To investigate the effect of vitamin D3 on patients with gestational diabetes mellitus(GDM).Methods 104 cases of GDM patients diagnosed and treated in the hospital from March 2019 to March 2020 were included in the study,and they were divided into study group and control group based on the random number table method;the control group received conventional treatment,and the study group took vitamin D3 preparation at the same time.Measure the levels of FPG and 25(OH)D in the two groups,and measure the levels of T lymphocyte subsets.Results After treatment,the FPG(4.03±0.22)mmol/L level of the study group was lower than that of the control group,and the 25(OH)D level(84.01±11.62)nmol/L increased.The difference between groups was statistically significant(P<0.05);After treatment,compared with the control group,the CD8+cells(30.25±4.83)%of the study group were significantly all reduced,and other cellular immune factors were increased.The difference between groups was statistically significant(P<0.05);after treatment,compared with the control group,the study group had differences was statistically significant in Th1,Th1/Th2 cells in patients(P<0.05).Conclusion Vitamin D3 supplementation can improve the blood sugar level of GDM patients,maintain the level of cellular immune factors in the body,and have a certain protective effect on immune function.