血清胱抑素C与肌酐、尿素氮联合检测在肾功能损害诊断中的运用分析

Application Analysis of Combined Detection of Serum Cystatin C,Creatinine and Urea Nitrogen in the Diagnosis of Renal Impairment

目的探讨肾功能损害诊断中运用尿素氮、肌酐以及血清胱抑素C联合检测的临床效果。方法选择2018年2月—2020年6月期间该院收治的75例肾功能损害患者为研究对象,根据肾功能损害程度将其分为3组,分别为肾功能衰竭组(n=20),肾功能不全失代偿组(n=25),肾功能不全代偿组(n=30),再选择同期的健康体检者90名为对照组,均行Cys-C、Scr以及BUN检测,并且比较各组检测结果。结果与对照组相比,肾功能不全失代偿组、肾功能不全代偿组以及肾功能衰竭组的Ccr水平较低,且Cys-C、Scr以及BUN水平均较高,组间比较差异有统计学意义(P<0.05);同时,血清Scr、BUN以及Cys-C与GFR水平呈反比关系(r=-0.492、-0.396、-0.636,P<0.05)。结论临床上将尿素氮、肌酐以及血清胱抑素C联合运用在肾功能损害诊断中,可以判断患者病情严重程度,为诊断和治疗提供有效依据。

Objective To investigate the clinical effect of combined detection of urea nitrogen,creatinine and serum cystatin C in the diagnosis of renal impairment.Methods 75 patients with renal impairment admitted to the hospital from February 2018 to June 2020 were selected as the research objects.According to the degree of renal impairment,they were divided into three groups,namely renal failure group(n=20),renal insufficiency decompensated group(n=25),renal insufficiency compensated group(n=30),and 90 healthy physical examination patients during the same period were selected as the control group,and Cys-C,Scr and BUN tests were performed,and compare the test results of each group.Results Compared with the control group,the Ccr levels of the renal insufficiency decompensated group,the renal insufficiency compensated group and the renal failure group are lower,and the levels of Cys-C,Scr and BUN are higher.There are statistical differences between the groups.Academic significance(P<0.05);at the same time,the serum Scr,BUN,and Cys-C levels were inversely proportional to GFR level(r=-0.492,-0.396,-0.636,P<0.05).Conclusion The clinical application of urea nitrogen,creatinine and serum cystatin C in the diagnosis of renal dysfunction can determine the severity of the patient's condition and provide an effective basis for diagnosis and treatment.